Seymour Jonathan Singer
Encyclopedia
Seymour Jonathan Singer is a cell biologist and professor at the University of California, San Diego. He worked as a postdoctoral fellow in the lab of Linus Pauling
at Caltech, where he co-discovered the basis of abnormal hemoglobin
in sickle-cell anemia, reported in the famous paper "Sickle Cell Anemia, a Molecular Disease
". In 1951, he became an assistant professor at Yale
, where he developed the ferritin
-antibody, which was the first electron-dense reagent used for cell staining in electron microscopy imaging. He was awarded a Guggenheim Fellowship
for Molecular & Cellular Biology in 1959. In 1961 he joined the faculty at UCSD. He then began to work on membrane proteins and aided in the development of the "Fluid Mosaic Model
" of the cell membrane. He later studied the cytoskeleton. In 2001, he published a book, "The Splendid Feast of Reason", regarding rationalism and the philosophy of science.
Linus Pauling
Linus Carl Pauling was an American chemist, biochemist, peace activist, author, and educator. He was one of the most influential chemists in history and ranks among the most important scientists of the 20th century...
at Caltech, where he co-discovered the basis of abnormal hemoglobin
Hemoglobin
Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...
in sickle-cell anemia, reported in the famous paper "Sickle Cell Anemia, a Molecular Disease
Sickle Cell Anemia, a Molecular Disease
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood...
". In 1951, he became an assistant professor at Yale
YALE
RapidMiner, formerly YALE , is an environment for machine learning, data mining, text mining, predictive analytics, and business analytics. It is used for research, education, training, rapid prototyping, application development, and industrial applications...
, where he developed the ferritin
Ferritin
Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. The amount of ferritin stored reflects the amount of iron stored. The protein is produced by almost all living organisms, including bacteria, algae and higher plants, and animals...
-antibody, which was the first electron-dense reagent used for cell staining in electron microscopy imaging. He was awarded a Guggenheim Fellowship
Guggenheim Fellowship
Guggenheim Fellowships are American grants that have been awarded annually since 1925 by the John Simon Guggenheim Memorial Foundation to those "who have demonstrated exceptional capacity for productive scholarship or exceptional creative ability in the arts." Each year, the foundation makes...
for Molecular & Cellular Biology in 1959. In 1961 he joined the faculty at UCSD. He then began to work on membrane proteins and aided in the development of the "Fluid Mosaic Model
Cell membrane
The cell membrane or plasma membrane is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. It basically protects the cell...
" of the cell membrane. He later studied the cytoskeleton. In 2001, he published a book, "The Splendid Feast of Reason", regarding rationalism and the philosophy of science.