Sarpogrelate
Encyclopedia
Sarpogrelate is a drug which acts as an antagonist at the 5HT2A
and 5-HT2B
receptor
s. It blocks serotonin-induced platelet aggregation, and has applications in the treatment of many diseases including diabetes mellitus
, Buerger's disease
, Raynaud's disease, coronary artery disease, angina pectoris, and atherosclerosis
.
5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor . This is the main excitatory receptor subtype among the GPCRs for serotonin , although 5-HT2A may also have an inhibitory effect on certain areas such...
and 5-HT2B
5-HT2B receptor
5-hydroxytryptamine receptor 2B, also known as HTR2B, is a 5-HT2 receptor, but also denotes the human gene encoding it.-Function:...
receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
s. It blocks serotonin-induced platelet aggregation, and has applications in the treatment of many diseases including diabetes mellitus
Diabetes mellitus
Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
, Buerger's disease
Buerger's disease
Thromboangiitis obliterans is a recurring progressive inflammation and thrombosis of small and medium arteries and veins of the hands and feet...
, Raynaud's disease, coronary artery disease, angina pectoris, and atherosclerosis
Atherosclerosis
Atherosclerosis is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol...
.