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Prolyl hydroxylase

 

 
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Prolyl hydroxylase
 
 
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Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen
Collagen

Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content....
, acting to hydroxylate proline
Proline

Proline is an a-amino acid, one of the twenty DNA-encoded amino acids. Its codons are CCU, CCC, CCA, and CCG. It is not an essential amino acid, which means that humans can synthesize it....
 to hydroxyproline
Hydroxyproline

4-Hydroxyproline, or hydroxyproline , is an uncommon amino acid, abbreviated as HYP, e.g., in Protein Data Bank....
.

It requires vitamin C
Vitamin C

Vitamin C or ascorbic acid is an essential nutrient for humans, a large number of simian species, a small number of other mammalian species , a few species of birds, and some fish....
 as a cofactor
Cofactor

Cofactor may refer to any of the following:* Cofactor The signed minor of a matrix* Minor as an alternative name for the determinant of a smaller Matrix than that which it describes...
.

Reaction: Proline + a-ketoglutarate + O2 + Fe2+ ? 4-hydroxyproline + Fe4+ + CO2 + succinate

The process requires ascorbic acid which provides Fe2+as a reductant to provide two electrons.

It is classified under .








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Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen
Collagen

Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content....
, acting to hydroxylate proline
Proline

Proline is an a-amino acid, one of the twenty DNA-encoded amino acids. Its codons are CCU, CCC, CCA, and CCG. It is not an essential amino acid, which means that humans can synthesize it....
 to hydroxyproline
Hydroxyproline

4-Hydroxyproline, or hydroxyproline , is an uncommon amino acid, abbreviated as HYP, e.g., in Protein Data Bank....
.

It requires vitamin C
Vitamin C

Vitamin C or ascorbic acid is an essential nutrient for humans, a large number of simian species, a small number of other mammalian species , a few species of birds, and some fish....
 as a cofactor
Cofactor

Cofactor may refer to any of the following:* Cofactor The signed minor of a matrix* Minor as an alternative name for the determinant of a smaller Matrix than that which it describes...
.

Reaction: Proline + a-ketoglutarate + O2 + Fe2+ ? 4-hydroxyproline + Fe4+ + CO2 + succinate

The process requires ascorbic acid which provides Fe2+as a reductant to provide two electrons.

It is classified under .

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