Profadol
Encyclopedia
Profadol is an opioid
analgesic
which was developed in the 1960s by Parke-Davis. It acts as a mixed agonist
-antagonist
of the μ-opioid receptor. The analgetic potency is about the same as of meperidine, the antagonistic effect is 1/50 of Nalorphine
.
Opioid
An opioid is a psychoactive chemical that works by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract...
analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
which was developed in the 1960s by Parke-Davis. It acts as a mixed agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
-antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
of the μ-opioid receptor. The analgetic potency is about the same as of meperidine, the antagonistic effect is 1/50 of Nalorphine
Nalorphine
Nalorphine trade names Lethidrone and Nalline. Nalorphine acts at two opioid receptors, at the mu receptor it has antagonistic effects and at the kappa receptors it exerts agonistic characteristics. It is used to reverse opioid overdose and in a challenge test to determine opioid dependence....
.