Protein polybromo-1 also known as BRG1-associated factor 180 (BAF180) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the PBRM1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Structure and function

Component of the SWI/SNF

SWI/SNF

SWI/SNF is a yeast nucleosome remodeling complex composed of several proteins – products of the SWI and SNF genes as well as several other polypeptides...

-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4

SMARCA4

Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.- Function :...

/BRG1, SMARCB1

SMARCB1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.-Interactions:...

/SNF5/INI1/BAF47, ACTL6A

ACTL6A

Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.-Interactions:ACTL6A has been shown to interact with SMARCA2, Myc, Transformation/transcription domain-associated protein, RuvB-like 1 and SMARCA4.-Further reading:...

/BAF53A or ACTL6B

ACTL6B

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.-Further reading:...

/BAF53B, SMARCE1

SMARCE1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.-Interactions:...

/BAF57, SMARCD1

SMARCD1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.-Interactions:SMARCD1 has been shown to interact with Glucocorticoid receptor.-Further reading:...

/BAF60A, SMARCD2

SMARCD2

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.-Further reading:...

/BAF60B, and actin

Actin

Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...

.

PB1 possesses 6 bromodomain

Bromodomain

A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha...

s, 2 bromo-adjacent homology (BAH) regions, and 1 high-mobility group (HMG) motif. PB1 is also homologous to yeast Rsc1, Rsc2, and Rsc4, essential proteins that are required for cell cycle

Cell cycle

The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

 progression through mitosis

Mitosis

Mitosis is the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets, in two separate nuclei. It is generally followed immediately by cytokinesis, which divides the nuclei, cytoplasm, organelles and cell membrane into two cells containing roughly...

.

Clinical significance

A mutant allele of PBRM1 has been strongly implicated as a cause of clear cell renal cell carcinoma.