Human parechovirus 1 (HPeV1) cis regulatory element (CRE)
Encyclopedia
The Human Parechovirus 1 cis regulatory element is an RNA element
which is located in the 5'-terminal 112 nucleotide
s of the genome of human parechovirus 1 (HPeV1). The element consists of two stem-loop
structures (SL-A and SL-B) together with a pseudoknot
. Disruption of any of these elements impairs both viral replication and growth.
Cis-regulatory element
A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...
which is located in the 5'-terminal 112 nucleotide
Nucleotide
Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...
s of the genome of human parechovirus 1 (HPeV1). The element consists of two stem-loop
Stem-loop
Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded DNA or, more commonly, in RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions,...
structures (SL-A and SL-B) together with a pseudoknot
Pseudoknot
A pseudoknot is a nucleic acid secondary structure containing at least two stem-loop structures in which half of one stem is intercalated between the two halves of another stem. The pseudoknot was first recognized in the turnip yellow mosaic virus in 1982...
. Disruption of any of these elements impairs both viral replication and growth.
See also
- Human rhinovirus internal cis-acting regulatory element (CRE)Human rhinovirus internal cis-acting regulatory element (CRE)Human rhinovirus internal cis-acting regulatory element isa CRE from the human rhinoviruses. The CRE is located within the genome segment encoding the capsid proteins so is found in a protein coding region...
- Rotavirus cis-acting replication element (CRE)Rotavirus cis-acting replication element (CRE)This family represents a rotavirus cis-acting replication element found at the 3'-end of rotavirus mRNAs. The family is thought to promote the synthesis of minus strand RNA to form viral dsRNA....