HMS Defiance was a 64-gun third rate ship of the line

Ship of the line

A ship of the line was a type of naval warship constructed from the 17th through the mid-19th century to take part in the naval tactic known as the line of battle, in which two columns of opposing warships would manoeuvre to bring the greatest weight of broadside guns to bear...

 of the English Royal Navy, ordered on 26 October 1664 under the new construction programme of that year, and launched on 27 March 1666 at William Castle's private shipyard at Deptford

Deptford

Deptford is a district of south London, England, located on the south bank of the River Thames. It is named after a ford of the River Ravensbourne, and from the mid 16th century to the late 19th was home to Deptford Dockyard, the first of the Royal Navy Dockyards.Deptford and the docks are...

 in the presence of King Charles II

Charles II of England

Charles II was monarch of the three kingdoms of England, Scotland, and Ireland.Charles II's father, King Charles I, was executed at Whitehall on 30 January 1649, at the climax of the English Civil War...

.

She was commissioned under Sir Robert Holmes and took part in the Four Days Battle

Four Days Battle

The Four Days Battle was a naval battle of the Second Anglo–Dutch War. Fought from 1 June to 4 June 1666 in the Julian or Old Style calendar then used in England off the Flemish and English coast, it remains one of the longest naval engagements in history.In June 1665 the English had soundly...

 on 1 June 1666—4 June 1666. Following the battle, Holmes was briefly replaced by Captain William Flawes, but a month later command was taken by Rear-Admiral Sir John Kempthorne

John Kempthorne (Royal Navy officer)

Sir John Kempthorne was an officer in the English Royal Navy during the Second and Third Anglo-Dutch Wars, who eventually rose to the rank of Vice-Admiral.-Childhood and early years:...

. In September 1667 Holmes, now Commander-in-Chief at Portsmouth, was back in command, but later that year he gave way to Sir John Harman in the same role. Defiance was accidentally destroyed by fire at Chatham on 6 December 1668.