GHKL domain
Encyclopedia
The GHKL domain is an evolutionary conserved protein domain
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This family represents the structurally related ATPase
domains of histidine kinase, DNA gyrase B and HSP90. This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins. More information about this protein can be found at Protein of the Month: DNA Topoisomerase.
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
.
This family represents the structurally related ATPase
ATPase
ATPases are a class of enzymes that catalyze the decomposition of adenosine triphosphate into adenosine diphosphate and a free phosphate ion. This dephosphorylation reaction releases energy, which the enzyme harnesses to drive other chemical reactions that would not otherwise occur...
domains of histidine kinase, DNA gyrase B and HSP90. This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins. More information about this protein can be found at Protein of the Month: DNA Topoisomerase.
Members
- BCKDKBCKDK[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial is an enzyme that in humans is encoded by the BCKDK gene.-Further reading:...
- HSP90AA1HSP90AA1Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene.-Interactions:Heat shock protein 90kDa alpha , member A1 has been shown to interact with TGF beta receptor 2, FKBP5, TGF beta receptor 1, Glucocorticoid receptor, AKT1, Hop, Peroxisome proliferator-activated...
, HSP90AB1HSP90AB1Heat shock protein HSP 90-beta is a protein that in humans is encoded by the HSP90AB1 gene.-Further reading:...
, HSP90B1HSP90B1Heat shock protein 90kDa beta member 1 , known also as endoplasmin, gp96, grp94 and ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene.... - MLH1MLH1MutL homolog 1, colon cancer, nonpolyposis type 2 , also known as MLH1, is a human gene located on Chromosome 3. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer.It can also be associated with Turcot syndrome....
, MLH3MLH3DNA mismatch repair protein Mlh3 is a protein that in humans is encoded by the MLH3 gene.-Further reading:...
, MORC1, MORC2MORC2MORC family CW-type zinc finger protein 2 is a protein that in humans is encoded by the MORC2 gene.-Further reading:...
, MORC3MORC3MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.-Further reading:...
, MORC4 - PDK1PDK1[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene. It codes for an isozyme of pyruvate dehydrogenase kinase ....
, PDK2PDK2Pyruvate dehydrogenase kinase isoform 2 also known as [pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the PDK2 gene. PDK2 is an isozyme of pyruvate dehydrogenase kinase....
, PDK3PDK3[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial is an enzyme that in humans is encoded by the PDK3 gene. It codes for an isozyme of pyruvate dehydrogenase kinase.- Interactive pathway map :-Further reading:...
, PDK4PDK4[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial is an enzyme that in humans is encoded by the PDK4 gene. It codes for an isozyme of pyruvate dehydrogenase kinase.... - PMS1PMS1PMS1 protein homolog 1 is a protein that in humans is encoded by the PMS1 gene.-Further reading:...
, PMS2PMS2Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the PMS2 gene.-Further reading:-External links:* from the National Institute of Health*...
, PMS2L1, PMS2L11, PMS2L3, PMS4L - TOP2ATOP2ADNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.-Interactions:TOP2A has been shown to interact with HDAC1, CDC5L, Small ubiquitin-related modifier 1 and P53.-Further reading:...
, TOP2BTOP2BDNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.-Interactions:TOP2B has been shown to interact with BAZ1B, HDAC1, Histone deacetylase 2, T-cell surface glycoprotein CD3 epsilon chain, Small ubiquitin-related modifier 1 and P53.-Further reading:... - TRAP1TRAP1Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.-Interactions:TRAP1 has been shown to interact with EXT2, EXT1 and Retinoblastoma protein.-Further reading:...
, TRRAP