ELMO3
Encyclopedia
Engulfment and cell motility 3, also known as ELMO3, is a human gene
.
The protein
encoded by this gene is similar to a C. elegans
protein that functions in phagocytosis of apoptotic
cells and in cell migration
. Other members of this small family of engulfment and cell motility (ELMO
) proteins have been shown to interact with the dedicator of cyto-kinesis 1 (DOCK1) protein to promote phagocytosis and effect cell shape changes.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
The protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by this gene is similar to a C. elegans
Caenorhabditis elegans
Caenorhabditis elegans is a free-living, transparent nematode , about 1 mm in length, which lives in temperate soil environments. Research into the molecular and developmental biology of C. elegans was begun in 1974 by Sydney Brenner and it has since been used extensively as a model...
protein that functions in phagocytosis of apoptotic
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
cells and in cell migration
Cell migration
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations...
. Other members of this small family of engulfment and cell motility (ELMO
ELMO (protein)
ELMO is a family of related proteins involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions.This family...
) proteins have been shown to interact with the dedicator of cyto-kinesis 1 (DOCK1) protein to promote phagocytosis and effect cell shape changes.