Dynamic combinatorial

Combinatorics

Combinatorics is a branch of mathematics concerning the study of finite or countable discrete structures. Aspects of combinatorics include counting the structures of a given kind and size , deciding when certain criteria can be met, and constructing and analyzing objects meeting the criteria ,...

 chemistry

Chemistry

Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....

is defined as combinatorial chemistry

Combinatorial chemistry

Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules or materials...

 under thermodynamic control.

Introduction

In a dynamic combinatorial library, all constituents are in equilibrium. The interconversion of library members into one another is through a reversible process that can involve covalent or non-covalent interactions. The composition of the library is determined by the thermodynamic stability of each of the library members under the particular conditions of the experiment.

Current Applications

DCC is useful in identifying molecules with unusual binding properties, and provides synthetic routes to complex molecules that aren't easily accessible by other means.

See also

• Combinatorial chemistry
  Combinatorial chemistry
  Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules or materials...
  
  
• Cheminformatics
  Cheminformatics
  Cheminformatics is the use of computer and informational techniques, applied to a range of problems in the field of chemistry. These in silico techniques are used in pharmaceutical companies in the process of drug discovery...
  
  
• Drug discovery
  Drug discovery
  In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered or designed.In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery...
  
  
• High-throughput screening
  High-throughput screening
  High-throughput screening is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Using robotics, data processing and control software, liquid handling devices, and sensitive detectors, High-Throughput Screening allows a...
  
  
• Mathematical chemistry
  Mathematical chemistry
  Mathematical chemistry is the area of research engaged in novel applications of mathematics to chemistry; it concerns itself principally with the mathematical modeling of chemical phenomena...
  
  
• Combinatorial biology
  Combinatorial biology
  In biotechnology, combinatorial biology is the creation of a large number of compounds through technologies such as phage display. Similar to combinatorial chemistry, compounds are produced by biosynthesis rather than organic chemistry. This process was developed independently by Richard A....