Desosamine
Encyclopedia
Desosamine is a 3--3,4,6-trideoxyhexose found in certain macrolide antibiotics
such as the commonly prescribed erythromycin
.
s are required for its biosynthesis from TDP-glucose in Streptomyces venezuelae.
Macrolide
The macrolides are a group of drugs whose activity stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered...
such as the commonly prescribed erythromycin
Erythromycin
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma and...
.
Biosynthesis
Six enzymeEnzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
s are required for its biosynthesis from TDP-glucose in Streptomyces venezuelae.