Coronavirus 3' UTR pseudoknot
Encyclopedia
The Coronavirus 3' UTR pseudoknot is an RNA
structure found in the coronavirus
genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genome
s. The 3' UTR region
of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot
structure which is necessary for viral genome replication. The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.
Other RNA families identified in the coronavirus include the coronavirus SL-III cis-acting replication element (CRE)
, the coronavirus frameshifting stimulation element
, the coronavirus 3' stem-loop II-like motif (s2m)
and the coronavirus packaging signal
.
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
structure found in the coronavirus
Coronavirus
Coronaviruses are species in the genera of virus belonging to the subfamily Coronavirinae in the family Coronaviridae. Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome and a helical symmetry. The genomic size of coronaviruses ranges from approximately 16 to 31...
genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genome
Genome
In modern molecular biology and genetics, the genome is the entirety of an organism's hereditary information. It is encoded either in DNA or, for many types of virus, in RNA. The genome includes both the genes and the non-coding sequences of the DNA/RNA....
s. The 3' UTR region
Three prime untranslated region
In molecular genetics, the three prime untranslated region is a particular section of messenger RNA . It is preceeded by the coding region....
of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot
Pseudoknot
A pseudoknot is a nucleic acid secondary structure containing at least two stem-loop structures in which half of one stem is intercalated between the two halves of another stem. The pseudoknot was first recognized in the turnip yellow mosaic virus in 1982...
structure which is necessary for viral genome replication. The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.
Other RNA families identified in the coronavirus include the coronavirus SL-III cis-acting replication element (CRE)
Coronavirus SL-III cis-acting replication element (CRE)
The coronavirus SL-III cis-acting replication element is an RNA element that regulates defective interfering RNA replication.Other RNA families identified in the coronavirus include the coronavirus 3' stem-loop II-like motif , the coronavirus frameshifting stimulation element, the coronavirus...
, the coronavirus frameshifting stimulation element
Coronavirus frameshifting stimulation element
In molecular biology, the coronavirus frameshifting stimulation element is a conserved stem-loop of RNA found in coronaviruses that can promote ribosomal frameshifting. Such RNA molecules interact with a downstream region to form a pseudoknot structure; the region varies according to the virus but...
, the coronavirus 3' stem-loop II-like motif (s2m)
Coronavirus 3' stem-loop II-like motif (s2m)
The Coronavirus 3' stem-loop II-like motif is a secondary structure motif identified in the 3'untranslated region of astrovirus, coronavirus and equine rhinovirus genomes...
and the coronavirus packaging signal
Coronavirus packaging signal
The Coronavirus packaging signal is a conserved cis-regulatory element found in Coronavirus which has an important role in regulating the packaging of the viral genome into the capsid....
.