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Bacteriophage MS2

 

 
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Bacteriophage MS2
 
 
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The bacteriophage MS2. MS2 phage is an icosahedral bacteriophage with a diameter of 27-34nm and an isoelectric point (pI) of 3.9. MS2 phage can be propagated in Escherichia coli, commonly E. coli ATCC 15597.

phage
Bacteriophage

A bacteriophage is any one of a number of viruses that infection bacteria. The term is commonly used in its shortened form, phage.Typically, bacteriophages consist of an outer protein hull enclosing genetic material....
 has a very small genome which is 3,569 nucleotides long. In 1976 the complete RNA
RNA

Ribonucleic acid is a type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nucleobase, a ribose sugar, and a phosphate....
 sequence of Bacteriophage MS2 was determined, compared to the DNA
DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetics instructions used in the development and functioning of all known living organisms and some viruses....
 sequence of the Phi-X174 phage
Phi-X174 phage

The phi X 174 bacteriophage was the first DNA-based genome to be sequenced. This work was completed by Fred Sanger and his team in 1977. In 1962, Walter Fiers had already demonstrated the physical, covalently closed circularity of phi X 174 DNA....
, which was determined by Fred Sanger and his team in 1977.






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The bacteriophage MS2. MS2 phage is an icosahedral bacteriophage with a diameter of 27-34nm and an isoelectric point (pI) of 3.9. MS2 phage can be propagated in Escherichia coli, commonly E. coli ATCC 15597.

Genetics

This phage
Bacteriophage

A bacteriophage is any one of a number of viruses that infection bacteria. The term is commonly used in its shortened form, phage.Typically, bacteriophages consist of an outer protein hull enclosing genetic material....
 has a very small genome which is 3,569 nucleotides long. In 1976 the complete RNA
RNA

Ribonucleic acid is a type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nucleobase, a ribose sugar, and a phosphate....
 sequence of Bacteriophage MS2 was determined, compared to the DNA
DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetics instructions used in the development and functioning of all known living organisms and some viruses....
 sequence of the Phi-X174 phage
Phi-X174 phage

The phi X 174 bacteriophage was the first DNA-based genome to be sequenced. This work was completed by Fred Sanger and his team in 1977. In 1962, Walter Fiers had already demonstrated the physical, covalently closed circularity of phi X 174 DNA....
, which was determined by Fred Sanger and his team in 1977. These two genomes were the first to be determined in scientific history.

In 1962 it was established that the RNA of the phage was in a ring-structure. In 1972 a gene of Bacteriophage MS2 was the first gene of which the nucleotide sequence was known. In 1976, it was the first complete genome to be sequenced, by Walter Fiers
Walter Fiers

Walter Fiers is a Belgium molecular biologist.He obtained a degree of Engineer for Chemistry and Agricultural Industries at the University of Ghent in 1954, and started his research career as an Enzyme in the laboratory of Laurent Vandendriessche in Ghent....
 and his team at the University of Ghent (Ghent
Ghent

Ghent is a city and a municipality located in the Flemish region, Belgium. It is the capital and biggest city of the East Flanders province. The city started as a settlement at the confluence of the Rivers Scheldt and Lys River and became in the Middle Ages one of the largest and richest cities of northern Europe....
, Belgium
Belgium

* A small German-speaking Community of Belgium exists in eastern Wallonia. Belgium's linguistic diversity and related political and cultural conflicts are reflected in the history of Belgium and a complex Communities and regions of Belgium....
).

See also

  • Phi-X174 phage
    Phi-X174 phage

    The phi X 174 bacteriophage was the first DNA-based genome to be sequenced. This work was completed by Fred Sanger and his team in 1977. In 1962, Walter Fiers had already demonstrated the physical, covalently closed circularity of phi X 174 DNA....
  • Bacteriophage
    Bacteriophage

    A bacteriophage is any one of a number of viruses that infection bacteria. The term is commonly used in its shortened form, phage.Typically, bacteriophages consist of an outer protein hull enclosing genetic material....