Acute myelomonocytic leukemia (AMMoL) is a form of
acute myeloid leukemiaAcute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...
that involves a proliferation of
CFU-GMCFU-GM is a colony forming unit. It is derived from CFU-GEMM.The "GM" stands for "granulocyte, monocyte".It is the precursor for monoblasts and myeloblasts.Production is stimulated by granulocyte macrophage colony-stimulating factor ....
myeloblastThe myeloblast is a unipotent stem cell, which will differentiate into one of the actors of the granular series.- Origin :These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these...
s and
monoblastMonoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes, which, in turn, develop into macrophages.-Structure:...
s.
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Acute myelomonocytic leukemia (AMMoL) is a form of
acute myeloid leukemiaAcute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...
that involves a proliferation of
CFU-GMCFU-GM is a colony forming unit. It is derived from CFU-GEMM.The "GM" stands for "granulocyte, monocyte".It is the precursor for monoblasts and myeloblasts.Production is stimulated by granulocyte macrophage colony-stimulating factor ....
myeloblastThe myeloblast is a unipotent stem cell, which will differentiate into one of the actors of the granular series.- Origin :These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these...
s and
monoblastMonoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes, which, in turn, develop into macrophages.-Structure:...
s.
It is classified under "M4" in the
French-American-British classificationThe French-American-British classification systems refers to a series of classifications of hematologic diseases.It was first produced in 1976.Types include:* FAB classification of acute lymphoblastic leukemias...
(FAB).
It is classified under "AML, not otherwise classified" in the WHO classification.
Translocations have been observed.
Progression from
myelodysplastic syndromeThe myelodysplastic syndromes are a diverse collection of hematological conditions united by ineffective production of myeloid blood cells and risk of transformation to acute myelogenous leukemia . MDS has been found in humans, cats and dogs. Anemia requiring chronic blood transfusion is...
has been reported.
External links
- Overview at Marist College
Marist College is a private liberal arts college of 180 acres , located on the east bank of the Hudson River near Poughkeepsie, New York, on US 9...
- Histology at University of Virginia
The University of Virginia is a public research university located in Charlottesville, Virginia, founded by Thomas Jefferson...
- Images at Nagoya University
, abbreviated to }}, is a Japanese national university headquartered in Chikusa-ku, Nagoya, and is considered as one of the most prestigious universities in Japan....