Acute myelomonocytic leukemia
Encyclopedia
Acute myelomonocytic leukemia (AMMoL) is a form of acute myeloid leukemia
that involves a proliferation of CFU-GM
myeloblast
s and monoblast
s.
It is classified under "M4" in the French-American-British classification
(FAB).
It is classified under "AML, not otherwise classified" in the WHO classification.
Translocations have been observed.
Progression from myelodysplastic syndrome
has been reported.
Acute myeloid leukemia
Acute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...
that involves a proliferation of CFU-GM
CFU-GM
CFU-GM is a colony forming unit. It is derived from CFU-GEMM.The "GM" stands for "granulocyte, monocyte".It is the precursor for monoblasts and myeloblasts....
myeloblast
Myeloblast
The myeloblast is a unipotent stem cell, which will differentiate into one of the actors of the Granulocyte series.- Origin :These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these...
s and monoblast
Monoblast
Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.-Structure:...
s.
It is classified under "M4" in the French-American-British classification
French-American-British classification
The French-American-British classification systems refers to a series of classifications of hematologic diseases.It was first produced in 1976.Types include:* FAB classification of acute lymphoblastic leukemias...
(FAB).
It is classified under "AML, not otherwise classified" in the WHO classification.
Translocations have been observed.
Progression from myelodysplastic syndrome
Myelodysplastic syndrome
The myelodysplastic syndromes are a diverse collection of hematological medical conditions that involve ineffective production of the myeloid class of blood cells....
has been reported.
External links
- Overview at Marist CollegeMarist CollegeMarist College is a private liberal arts college on the east bank of the Hudson River near Poughkeepsie, New York. The site was established in 1905 by Marist Brothers, and the college was chartered in 1929...
- Histology at University of VirginiaUniversity of VirginiaThe University of Virginia is a public research university located in Charlottesville, Virginia, United States, founded by Thomas Jefferson...
- Images at Nagoya UniversityNagoya UniversityNagoya University is one of the most prestigious universities in Japan. It can be seen in the several rankings such as shown below.-General Rankings:...