CFU-GM is a colony forming unit. It is derived from
CFU-GEMMCFU-GEMM is a colony forming unit that generates myeloid cells.CFU-GEMM cells are multipotential progenitor cells.The "GEMM" stands for ""granulocyte, erythrocyte, monocyte, megakaryocyte".CFU-GEMM gives rise to CFU-GM....
.
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CFU-GM is a colony forming unit. It is derived from
CFU-GEMMCFU-GEMM is a colony forming unit that generates myeloid cells.CFU-GEMM cells are multipotential progenitor cells.The "GEMM" stands for ""granulocyte, erythrocyte, monocyte, megakaryocyte".CFU-GEMM gives rise to CFU-GM....
.
The "GM" stands for "
granulocyteGranulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes because of the varying shapes of the nucleus, which is usually lobed into three segments...
,
monocyteMonocyte is a type of white blood cell, part of the human body's immune system. Monocytes have two main functions in the immune system: replenish resident macrophages and dendritic cells under normal states, and in response to inflammation signals, monocytes can move quickly Monocyte is a type of...
".
It is the precursor for
monoblastMonoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes, which, in turn, develop into macrophages.-Structure:...
s and
myeloblastThe myeloblast is a unipotent stem cell, which will differentiate into one of the actors of the granular series.- Origin :These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these...
s.
Production is stimulated by
granulocyte macrophage colony-stimulating factorGranulocyte-macrophage colony-stimulating factor, often abbreviated to GM-CSF, is a protein secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts.-Functions:...
(GM-CSF).
Granulocytes
There is some controversy over which
granulocyteGranulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes because of the varying shapes of the nucleus, which is usually lobed into three segments...
s derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos
CFU-Eo is a colony forming unit.It gives rise to eosinophils.Some sources prefer the term "CFU-Eos".It is also known as "hEoP"....
".
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso
CFU-Baso is a colony forming unit.It gives rise to basophils.Some sources use the term "CFU-Bas"....
".