CFU-GM
Encyclopedia
CFU-GM is a colony forming unit. It is derived from CFU-GEMM
.
The "GM" stands for "granulocyte
, monocyte
".
It is the precursor for monoblast
s and myeloblast
s.
Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
s derive from CFU-GM.
CFU-GEMM
CFU-GEMM is a colony forming unit that generates myeloid cells.CFU-GEMM cells are multipotential progenitor cells.The "GEMM" stands for ""granulocyte, erythrocyte, monocyte, megakaryocyte".CFU-GEMM gives rise to CFU-GM....
.
The "GM" stands for "granulocyte
Granulocyte
Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes because of the varying shapes of the nucleus, which is usually lobed into three segments...
, monocyte
Monocyte
Monocytes are a type of white blood cell and are part of the innate immune system of vertebrates including all mammals , birds, reptiles, and fish. Monocytes play multiple roles in immune function...
".
It is the precursor for monoblast
Monoblast
Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.-Structure:...
s and myeloblast
Myeloblast
The myeloblast is a unipotent stem cell, which will differentiate into one of the actors of the Granulocyte series.- Origin :These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these...
s.
Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
Granulocytes
There is some controversy over which granulocyteGranulocyte
Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes because of the varying shapes of the nucleus, which is usually lobed into three segments...
s derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-EosCFU-EosCFU-Eo is a colony forming unit.It gives rise to eosinophils.Some sources prefer the term "CFU-Eos".It is also known as "hEoP"....
".
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-BasoCFU-BasoCFU-Baso is a colony forming unit.It gives rise to basophils.Some sources use the term "CFU-Bas"....
".