ADAMTS is a family of peptidases. 19 members of this family have been identified in humans. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor

Von Willebrand factor

von Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...

 as well as cleavage of aggrecan

Aggrecan

Aggrecan also known as cartilage-specific proteoglycan core protein or chondroitin sulfate proteoglycan 1 is a protein that in humans is encoded by the ACAN gene. This gene is a member of the aggrecan/versican proteoglycan family...

, versican

Versican

Versican, also known as VCAN, is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene....

, brevican and neurocan. They have been demonstrated to have important roles in connective tissue organization, coagulation

Coagulation

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...

, inflammation, arthritis

Arthritis

Arthritis is a form of joint disorder that involves inflammation of one or more joints....

, angiogenesis

Angiogenesis

Angiogenesis is the physiological process involving the growth of new blood vessels from pre-existing vessels. Though there has been some debate over terminology, vasculogenesis is the term used for spontaneous blood-vessel formation, and intussusception is the term for the formation of new blood...

 and cell migration.

Family members are:

• ADAMTS1
  ADAMTS1
  A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.-Interactions:ADAMTS1 has been shown to interact with Vascular endothelial growth factor A.-External Links:...
  
  
• ADAMTS2
  ADAMTS2
  A disintegrin and metalloproteinase with thrombospondin motifs 2 also known as procollagen I N-proteinase is an enzyme that in humans is encoded by the ADAMTS2 gene.- Gene :...
  
  
• ADAMTS3
  ADAMTS3
  A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.-External Links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAMTS4
  ADAMTS4
  A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAMTS5
  ADAMTS5
  A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene.- Function :...
  
   (=ADAMTS11)
• ADAMTS6
• ADAMTS7
• ADAMTS8
  ADAMTS8
  A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.- Function :...
  
   (or METH-2), an antiangiogenic
• ADAMTS9
  ADAMTS9
  A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.-External Links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAMTS10
  ADAMTS10
  A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.-External Links:* * The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAMTS12
  ADAMTS12
  A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.-External Links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAMTS13
  ADAMTS13
  ADAMTS13 —also known as von Willebrand factor-cleaving protease —is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor , a large protein involved in blood clotting...
  
  
• ADAMTS14
• ADAMTS15
• ADAMTS16
• ADAMTS17
• ADAMTS18
• ADAMTS19
• ADAMTS20