ZFP57
Encyclopedia
Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein
that in humans is encoded by the ZFP57 gene
.
protein containing a KRAB domain
. Studies in mouse suggest that this protein may function as a transcriptional repressor
.
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the ZFP57 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The protein encoded by this gene is a zinc fingerZinc finger
Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...
protein containing a KRAB domain
Krüppel associated box
The Krüppel associated box domain is a category of transcriptional repression domains present in approximately 200 human zinc finger protein-based transcription factors. The KRAB domain typically consists of about 75 amino acid residues whilst the minimal repression module is approximately 45...
. Studies in mouse suggest that this protein may function as a transcriptional repressor
Repressor
In molecular genetics, a repressor is a DNA-binding protein that regulates the expression of one or more genes by binding to the operator and blocking the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes. This blocking of expression is called...
.
Clinical significance
Mutations in the ZFP57 gene may be associated with transient neonatal diabetes mellitusTransient neonatal diabetes mellitus
Transient neonatal diabetes mellitus is a form of diabetes mellitus presenting at birth that is not permanent.Types include:It is to do with genetics and is often associated with having an added Chromosome 7 gene ....
.