Umbellulone
Encyclopedia
Umbellulone is a headache
Headache
A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions of the head and neck. The brain tissue itself is not sensitive to pain because it lacks pain receptors. Rather, the pain is caused by disturbance of the...

-inducing monoterpene
Monoterpene
Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16. Monoterpenes may be linear or contain rings...

 ketone
Ketone
In organic chemistry, a ketone is an organic compound with the structure RCR', where R and R' can be a variety of atoms and groups of atoms. It features a carbonyl group bonded to two other carbon atoms. Many ketones are known and many are of great importance in industry and in biology...

 found in the leaves of the tree Umbellularia californica, sometimes known as the "headache tree". It is hypothesized to cause headaches by influencing the trigeminovascular system
Trigeminovascular system
The trigeminovascular system consists of neurons in the trigeminal nerve that innervate cerebral blood vessels. It has been hypothesized that the trigeminovascular system may be involved in some types of headaches.- External links :* * *...

 via TRPA1
TRPA1
Transient receptor potential cation channel, subfamily A, member 1, also known as TRPA1, is a protein which in humans is encoded by the TRPA1 gene....

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