All Topics  
Tumor necrosis factors

 

 
   Email Print
   Bookmark   Link
 

 

Tumor necrosis factors
 
 
  Topics Tumor necrosis factors Topic Home

Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family that can cause cell death.

he end of 19th century William Coley
William Coley

Dr. William Coley was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy. He developed a treatment based on provoking an immune response to bacteria....
, a New York
New York

The State of New York is a U.S. state in the Mid-Atlantic States and Northeastern United States regions of the United States and is the nation's List of U.S....
 surgeon, described remission of tumours following bacterial infection. In 1975 a protein responsible for this process was identified and called tumor necrosis factor alpha (TNF-alpha).

An article on the history of fever therapy, as it was called, and TNF up to 1991, with references to clinical and double-blind studies but under the heading of complementary and alternative therapies, has been published.

acts via the TNF Receptor (TNF-R) and is part of the extrinsic pathway for triggering apoptosis
Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Programmed Cell death involves a series of biochemical events leading to a characteristic cell Morphology and death, in more specific terms, a series of biochemical events that lead to a variety of morphological changes, including Bleb , changes...
.






Discussion
Ask a question about 'Tumor necrosis factors'
Start a new discussion about 'Tumor necrosis factors'
Answer questions from other users
Full Discussion Forum



Encyclopedia


Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family that can cause cell death.

History

At the end of 19th century William Coley
William Coley

Dr. William Coley was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy. He developed a treatment based on provoking an immune response to bacteria....
, a New York
New York

The State of New York is a U.S. state in the Mid-Atlantic States and Northeastern United States regions of the United States and is the nation's List of U.S....
 surgeon, described remission of tumours following bacterial infection. In 1975 a protein responsible for this process was identified and called tumor necrosis factor alpha (TNF-alpha).

An article on the history of fever therapy, as it was called, and TNF up to 1991, with references to clinical and double-blind studies but under the heading of complementary and alternative therapies, has been published.

Mechanism

TNF acts via the TNF Receptor (TNF-R) and is part of the extrinsic pathway for triggering apoptosis
Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Programmed Cell death involves a series of biochemical events leading to a characteristic cell Morphology and death, in more specific terms, a series of biochemical events that lead to a variety of morphological changes, including Bleb , changes...
. TNF-R is associated with procaspases through adapter proteins (FADD, TRADD, etc.) that can cleave other inactive procaspases and trigger the caspase cascade, irreversibly committing the cell to apoptosis
Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Programmed Cell death involves a series of biochemical events leading to a characteristic cell Morphology and death, in more specific terms, a series of biochemical events that lead to a variety of morphological changes, including Bleb , changes...
.

TNF interacts with tumor cells to trigger cytolysis or cell death.

TNF interact with receptors on endothelial cells, which leads to increased vascular permeability allowing leukocytes access to the site of infection. This is a type of localized inflammatory response, although systemic release may lead to septic shock and death.

Types

  • Tumor necrosis factor-alpha (TNF-a) is the most well-known member of this class, and sometimes referred to when the term "tumor necrosis factor" is used.


  • Tumor necrosis factor-beta (TNF-ß) is a cytokine that is induced by interleukin 10
    Interleukin 10

    Interleukin-10 , also known as human cytokine synthesis inhibitory factor , is an anti-inflammatory cytokine.This cytokine is produced primarily by monocytes and to a lesser extent by lymphocytes....
     


External links