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Subcapsular sinus
 
 
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The subcapsular sinus (lymph path, lymph sinus, marginal sinus) is a region within the lymph node
Lymph node

A Lymph node is an organ consisting of many types of cells, and is a part of the lymphatic system. Lymph nodes are found all through the body, and act as filters or traps for foreign particles....
 immediately deep to the capsule that contains relatively sparse lymphocyte
Lymphocyte

A lymphocyte is a type of white blood cell in the vertebrate immune system.By their appearance under the light microscope, there are two broad categories of lymphocytes, namely the large granular lymphocytes and the small lymphocytes....
s. It thus allows lymph
Lymph

Lymph is the fluid that is formed as the interstitial fluid. It enters the lymph vessels by filtration. The lymph then travels to at least one lymph node before emptying ultimately into the right or the left subclavian vein, where it mixes back with blood....
 to flow freely through it.

The lymph node contains lymphoid tissue, i.e., a meshwork or fibers called reticulum with white blood cell
White blood cell

White blood cells , or leukocytes , are cell of the immune system defending the body against both infectious disease and foreign materials....
s enmeshed in it. The regions where there are few cells within the meshwork are known lymph sinus.






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The subcapsular sinus (lymph path, lymph sinus, marginal sinus) is a region within the lymph node
Lymph node

A Lymph node is an organ consisting of many types of cells, and is a part of the lymphatic system. Lymph nodes are found all through the body, and act as filters or traps for foreign particles....
 immediately deep to the capsule that contains relatively sparse lymphocyte
Lymphocyte

A lymphocyte is a type of white blood cell in the vertebrate immune system.By their appearance under the light microscope, there are two broad categories of lymphocytes, namely the large granular lymphocytes and the small lymphocytes....
s. It thus allows lymph
Lymph

Lymph is the fluid that is formed as the interstitial fluid. It enters the lymph vessels by filtration. The lymph then travels to at least one lymph node before emptying ultimately into the right or the left subclavian vein, where it mixes back with blood....
 to flow freely through it.

The lymph node contains lymphoid tissue, i.e., a meshwork or fibers called reticulum with white blood cell
White blood cell

White blood cells , or leukocytes , are cell of the immune system defending the body against both infectious disease and foreign materials....
s enmeshed in it. The regions where there are few cells within the meshwork are known lymph sinus. It is lined by reticular cells, fibroblast
Fibroblast

A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen , the structural framework for animal tissues, and play a critical role in wound healing....
s and fixed macrophage
Macrophage

Macrophages are white blood cells within tissues, produced by the division of monocytes. Human macrophages are about 21 micrometres in diameter....
s.

Thus, subcapsular (sub=below) sinus lies immediately deep to the capsule of the lymph node and immediately above the cortex. It is continuous with the similar lymph sinuses that flank the trabeculae (the extensions of capsule within the substance of the lymph node).

The subcapsular sinus is of clinical importance as it is the most likely location where the earliest manifestations of a metastatic carcinoma in a lymph node would be found.

External links

- "Lymphoid Tissues and Organs: lymph node, afferent arterioles"