Steven M. Weinreb
Encyclopedia
Steven M. Weinreb is an American
chemist
and is a professor of chemistry at Pennsylvania State University
in United States. Together with Steven Nahm, he discovered the Weinreb ketone synthesis
, which allows for mono-addition of an organometallic reagent such as a Grignard reagent
or organolithium reagent
to an amide.
Weinreb received his PhD. for work with Marshall Gates at the University of Rochester
in 1967. After post-docs with Gilbert Stork
and George H. Buchi, he worked at Fordham University
. He joined the Pennsylvania State University in 1978, where he holds the Russell and Mildred Marker Professor of Natural Products Chemistry chair.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
chemist
Chemist
A chemist is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties such as density and acidity. Chemists carefully describe the properties they study in terms of quantities, with detail on the level of molecules and their component atoms...
and is a professor of chemistry at Pennsylvania State University
Pennsylvania State University
The Pennsylvania State University, commonly referred to as Penn State or PSU, is a public research university with campuses and facilities throughout the state of Pennsylvania, United States. Founded in 1855, the university has a threefold mission of teaching, research, and public service...
in United States. Together with Steven Nahm, he discovered the Weinreb ketone synthesis
Weinreb ketone synthesis
The Weinreb ketone synthesis is a chemical reaction used in organic chemistry to make carbon–carbon bonds. It was discovered in 1981 by Steven M. Weinreb and Steven Nahm as a method to synthesize ketones...
, which allows for mono-addition of an organometallic reagent such as a Grignard reagent
Grignard reaction
The Grignard reaction is an organometallic chemical reaction in which alkyl- or aryl-magnesium halides add to a carbonyl group in an aldehyde or ketone. This reaction is an important tool for the formation of carbon–carbon bonds...
or organolithium reagent
Organolithium reagent
An organolithium reagent is an organometallic compound with a direct bond between a carbon and a lithium atom. As the electropositive nature of lithium puts most of the charge density of the bond on the carbon atom, effectively creating a carbanion, organolithium compounds are extremely powerful...
to an amide.
Weinreb received his PhD. for work with Marshall Gates at the University of Rochester
University of Rochester
The University of Rochester is a private, nonsectarian, research university in Rochester, New York, United States. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The university has six schools and various interdisciplinary programs.The...
in 1967. After post-docs with Gilbert Stork
Gilbert Stork
Gilbert Stork is a U.S. organic chemist. He is the Eugene Higgins Professor of Chemistry Emeritus at Columbia University. The Stork enamine synthesis is named in his honor.-Education:...
and George H. Buchi, he worked at Fordham University
Fordham University
Fordham University is a private, nonprofit, coeducational research university in the United States, with three campuses in and around New York City. It was founded by the Roman Catholic Diocese of New York in 1841 as St...
. He joined the Pennsylvania State University in 1978, where he holds the Russell and Mildred Marker Professor of Natural Products Chemistry chair.