Sterol carrier protein
Encyclopedia
Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroid
s and probably also phospholipid
s and ganglioside
s between cellular membranes.
These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from Thermus thermophilus
.
This domain is involved in binding sterols. The human sterol carrier protein 2 (SCP2
) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids.
Steroid
A steroid is a type of organic compound that contains a characteristic arrangement of four cycloalkane rings that are joined to each other. Examples of steroids include the dietary fat cholesterol, the sex hormones estradiol and testosterone, and the anti-inflammatory drug dexamethasone.The core...
s and probably also phospholipid
Phospholipid
Phospholipids are a class of lipids that are a major component of all cell membranes as they can form lipid bilayers. Most phospholipids contain a diglyceride, a phosphate group, and a simple organic molecule such as choline; one exception to this rule is sphingomyelin, which is derived from...
s and ganglioside
Ganglioside
Ganglioside is a molecule composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain. The 60+ known gangliosides differ mainly in the position and number of NANA residues.It is a component of the cell plasma membrane that modulates cell signal transduction events...
s between cellular membranes.
These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from Thermus thermophilus
Thermus thermophilus
Thermus thermophilus is a Gram negative eubacterium used in a range of biotechnological applications, including as a model organism for genetic manipulation, structural genomics, and systems biology. The bacterium is extremely thermophilic, with an optimal growth temperature of about...
.
This domain is involved in binding sterols. The human sterol carrier protein 2 (SCP2
SCP2
Non-specific lipid-transfer protein also known as sterol carrier protein 2 or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene.- Function :...
) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids.
External links
- Sterol carrier proteins in SCOPStructural Classification of ProteinsThe Structural Classification of Proteins database is a largely manual classification of protein structural domains based on similarities of their structures and amino acid sequences. A motivation for this classification is to determine the evolutionary relationship between proteins...
- SCP-2 sterol transfer family in PfamPfamPfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models.- Features :For each family in Pfam one can:* Look at multiple alignments* View protein domain architectures...