Spectinomycin

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Spectinomycin

Spectinomycin (marketed as the hydrochloride

Hydrochloride

In chemistry, hydrochlorides are salt s resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic Base . This is also known as muriate, derived from hydrochloric acid's other name: muriatic acid....
salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol

Aminocyclitol

Cyclitols are cycloalkanes containing one hydroxyl group on each of three or more ring atoms. These compounds, and others closely related to them, possess features of relative and absolute configuration that are characteristic of their class and have been extensively studied; but these features are not clearly displayed by general methods of stereo...
antibiotic

Antibiotic

In common usage, an antibiotic is a substance or compound that kills or inhibits the growth of bacteria. Antibiotics belong to the group of antimicrobial compounds used to treat infections caused by microorganisms, including fungus and protozoa....
produced by the bacterium

Bacteria

The Bacteria are a large group of unicellular microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals....
Streptomyces spectabilis.

There was a disruption in the supply in 2001.

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Encyclopedia

Spectinomycin (marketed as the hydrochloride

Hydrochloride

Aminocyclitol

Antibiotic

Bacteria

Mechanism

It binds to the 30S

30s

Events and Trends*circa 33 ? Jesus is Good Friday and, according to Christian doctrine, is Easter.*Establishment of a Christian church at Antioch, the forerunner of churches in the Syriac Christianity tradition....
ribosomal

Ribosome

Ribosomes are complexes of RNA and protein that are found in all cell s. Ribosomes from bacteria, archaea and eukaryotes, the three domains of life on Earth, have significantly different structure and RNA....
subunit in invading bacteria and interrupts protein synthesis.

One form of resistance has emerged in the 16S ribosomal RNA

16S ribosomal RNA

The 16Svedberg rRNA is a 1542 nt long component of the small prokaryotic ribosomal subunit .It is possible for multiple sequences to exist in a single bacterium....
in Pasteurella multocida

Pasteurella multocida

Pasteurella multocida is a Gram-negative, non-motile coccobacillus that is penicillin-sensitive and belongs to the Pasteurellaceae family . It can cause a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets....
.

Uses

It is given by injection

Injection (medicine)

An injection is an route of administration of putting liquid into the body, usually with a hollow hypodermic needle and a syringe which is pierced through the skin to a sufficient depth for the material to be forced into the body....
to treat gonorrhea

Gonorrhea

Gonorrhea is caused by the bacterium Neisseria gonorrhoeae and is a common sexually transmitted infection. In the US, its incidence is second only to Chlamydia infection....
, especially in patients who are allergic to penicillin

Penicillin

Penicillin is a group of antibiotics derived from Penicillium fungi. They are Beta-lactam antibiotics used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms....
s.

Side effects

Side effects include itching, chills, stomach-ache, and red rash

Erythema

Erythema is redness of the skin caused by capillary congestion....
.