Small Nucleolar RNA SNORD64
Encyclopedia
SNORD64 is a non-coding RNA
(ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNA
s (snRNAs). This type of modifiying RNA is located in the nucleolus
of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
(snoRNA) and also often referred to as a guide RNA.
SNORD64 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation
of substrate RNAs.
snoRNA HBII-13 is expressed mainly in the tissues of brain, but is also in the lungs, the kidneys and muscle however HBII-13 has no identified target RNA . The HBII-13 gene is located in a 460 kb intron
of the large, paternally expressed, transcription unit (SNURF-SNRNP-UBE3A AS) along with several other snoRNAs HBII-436, HBII-437, HBII-438A/B and the clusters of HBII-85, HBII-52
. This host gene is an antisense transcript to maternally expressed UBE3A gene.
Non-coding RNA
A non-coding RNA is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA , non-messenger RNA and functional RNA . The term small RNA is often used for short bacterial ncRNAs...
(ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNA
Small nuclear RNA
Small nuclear ribonucleic acid is a class of small RNA molecules that are found within the nucleus of eukaryotic cells. They are transcribed by RNA polymerase II or RNA polymerase III and are involved in a variety of important processes such as RNA splicing , regulation of transcription factors ...
s (snRNAs). This type of modifiying RNA is located in the nucleolus
Nucleolus
The nucleolus is a non-membrane bound structure composed of proteins and nucleic acids found within the nucleus. Ribosomal RNA is transcribed and assembled within the nucleolus...
of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
SnoRNA
Small nucleolar RNAs are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs...
(snoRNA) and also often referred to as a guide RNA.
SNORD64 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation
Methylation
In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with, to be specific, a methyl group, rather than a larger carbon chain, replacing a hydrogen atom...
of substrate RNAs.
snoRNA HBII-13 is expressed mainly in the tissues of brain, but is also in the lungs, the kidneys and muscle however HBII-13 has no identified target RNA . The HBII-13 gene is located in a 460 kb intron
Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing to generate the final mature RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts. Sequences that are joined together in the final...
of the large, paternally expressed, transcription unit (SNURF-SNRNP-UBE3A AS) along with several other snoRNAs HBII-436, HBII-437, HBII-438A/B and the clusters of HBII-85, HBII-52
. This host gene is an antisense transcript to maternally expressed UBE3A gene.