Semicarbazide
Encyclopedia
In organic chemistry
, semicarbazide is a derivative of urea
, where NH2 on one side has been replaced with H2NNH2 hydrazine
, yielding H2NNHC(=O)NH2.
Semicarbazide is used as a detection reagent on thin layer chromatography
(TLC). Semicarbazide stains α-keto acids on the TLC plate, which must then be viewed under a UV light to see the results.
A thiosemicarbazide is an analog with a sulfur atom in place of the oxygen atom.
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
, semicarbazide is a derivative of urea
Urea
Urea or carbamide is an organic compound with the chemical formula CO2. The molecule has two —NH2 groups joined by a carbonyl functional group....
, where NH2 on one side has been replaced with H2NNH2 hydrazine
Hydrazine
Hydrazine is an inorganic compound with the formula N2H4. It is a colourless flammable liquid with an ammonia-like odor. Hydrazine is highly toxic and dangerously unstable unless handled in solution. Approximately 260,000 tons are manufactured annually...
, yielding H2NNHC(=O)NH2.
Semicarbazide is used as a detection reagent on thin layer chromatography
Thin layer chromatography
Thin layer chromatography is a chromatography technique used to separate mixtures. Thin layer chromatography is performed on a sheet of glass, plastic, or aluminum foil, which is coated with a thin layer of adsorbent material, usually silica gel, aluminium oxide, or cellulose...
(TLC). Semicarbazide stains α-keto acids on the TLC plate, which must then be viewed under a UV light to see the results.
A thiosemicarbazide is an analog with a sulfur atom in place of the oxygen atom.
See also
- SemicarbazoneSemicarbazoneIn organic chemistry, a semicarbazone is a derivative of an aldehyde or ketone formed by a condensation reaction between a ketone or aldehyde and semicarbazide.For ketones:For aldehydes:...
- Carbazone
- CarbazideCarbazideIn chemistry, carbazide is a functional group formally derived from the condensation of carbonic acid with a hydrazine derivative....
- Antitumor Drugs
- Semicarbazide-Cadmium TherapySemicarbazide-cadmium therapySemicarbazide-cadmium therapy was an experimental cancer therapy that was tested in several clinical trials in Russia during the 1960s. Semicarbazide is an irreversible inhibitor of semicarbazide-sensitive amine oxidase , an enzyme possibly involved in exacerbation of inflammation...