Scedosporium prolificans is an emerging opportunist fungus

Fungus

A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds , as well as the more familiar mushrooms. These organisms are classified as a kingdom, Fungi, which is separate from plants, animals, and bacteria...

 that causes different types of infections in immunocompetent and immunosuppressed people. Originally named Lomentospora prolificans in 1974, it was transferred to the genus Scedosporium in 1991.
It is resistant to most antifungal drugs and infections are often fatal. Successful control of disseminated Scedosporium prolificans infection can be obtained with a combination of voriconazole

Voriconazole

Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections.-Invasive...

 and terbinafine

Terbinafine

Terbinafine hydrochloride is a...

, but some strains are resistant to this treatment. Drugs that might also be of help are posaconazole

Posaconazole

Posaconazole is a triazole antifungal drug.Posaconazole is marketed in the United States, the European Union, and in other countries by Schering-Plough under the trade name Noxafil...

, miltefosine

Miltefosine

Miltefosine is a phospholipid drug.Originally developed as an antineoplastic , it is finding use as an antiprotozoal drug...

 and albaconazole

Albaconazole

Albaconazole is a triazole antifungal. It has potential broad-spectrum activity....

. Albaconazole is in Phase III clinical trials.