Sankar Ghosh
Encyclopedia
Sankar Ghosh is an India
n immunologist and microbiologist
, who is the chair of the Department of Microbiology & Immunology at Columbia University Medical Center
. Previously he has remained a Professor of Immunobiology, Molecular Biophysics
and Biochemistry
, and Molecular
, Cellular
& Developmental Biology
, and researcher working at Yale University
for 17 years.
Sankar Ghosh's particular area of research is focused on the activation of cellular responses via the inducible transcription factor, NF-κB.
, 1981; M.S. Albert Einstein College of Medicine
, New York
(Yeshiva University
), 1984; He received his Ph.D.
, from Albert Einstein College of Medicine, New York, in 1988, and thereafter he did his postdoctoral work at the Whitehead Institute
, Cambridge, Massachusetts
(MIT), under the supervision of Nobel laureate David Baltimore
(1989–1991).
faculty, in 1991, and worked there for the next 17 year as Professor of Immunobiology; Molecular, Cellular, and Developmental Biology; and Molecular Biophysics and Biochemistry at Yale University School of Medicine, till he moved to Columbia University
in 2008, where he became Chair Department of Microbiology at Columbia University Medical Center
.
In 2002, he was named a Howard Hughes Medical Investigator by Howard Hughes Medical Institute
. He was also awarded the Ranbaxy Science Foundation's Annual Research Awards for the year 2005, the foundation is a non-profit organization set-up by Ranbaxy Laboratories
Limited (RLL)., then in 2007 he was named as a Fellow of the AAAS
, by the American Association for the Advancement of Science
(AAAS), for "distinguished contributions to the field of immunology, particularly for studies of the NF-êB signaling pathway." .
Shim, J.H., et al. TAK1, but not TAB1 or TA B2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005 Nov 15
Jimi, E. and S. Ghosh. Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev. 2005 Dec.
Jimi, E. et al. Activation of NF-{kappa}B promo tes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol. 20 May 2005
Bailey ST, Ghosh S. 'PPAR'ting ways with inflammation. Nat Immunol., 2005 Oct 6
E. C. Ziegler, S. Ghosh, Regulating Inducible Transcription Through Controlled Localization. Sci. STKE 2005, re6 (2005).
di Meglio, P., A. Ianaro, and S. Ghosh, Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum, 2005. 52(3): p. 951-8.
Lee, K.Y., et al., PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science, 2005. 308(5718): p. 114-8.
Hayden, M.S. and S. Ghosh, Signaling to NF-kappaB. Genes Dev, 2004. 18(18): p. 2195-224.
Zhang, D., et al., A toll-like receptor that prevents infection by uropathogenic bacteria. Science, 2004. 303(5663): p. 1522-6.
Jimi, E., et al., Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med, 2004. 10(6): p. 617-24.
Marienfeld, R., et al., RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem, 2003. 278(22): p. 19852-60.
Ma, X.Y., et al., The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem, 2003. 278(25): p. 23008-19.
Wu, C. and S. Ghosh, Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases. J Biol Chem, 2003. 278(34): p. 31980-7.
May, M.J., R.B. Marienfeld, and S. Ghosh, Characterization of the Ikappa B-kinase NEMO binding domain. J Biol Chem, 2002. 277(48): p. 45992-6000.
Zhang, G. and S. Ghosh, Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem, 2002. 277(9): p. 7059-65.
Zhong, H., et al., The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell, 2002. 9(3): p. 625-36.
D'Acquisto, F., M.J. May, and S. Ghosh, Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies. Mol Interv, 2002. 2(1): p. 22-35.
Budde, L.M., et al., Regulation of IkappaBbeta expression in testis. Mol Biol Cell, 2002. 13(12): p. 4179-94.
Ghosh, S. and M. Karin, Missing pieces in the NF-kappaB puzzle. Cell, 2002. 109 Suppl: p. S81-96.
D'Acquisto, F. and S. Ghosh, PACT and PKR: turning on NF-kappa B in the absence of virus. Sci STKE, 200 1. 2001(89): p. RE1.
Zhang, G. and S. Ghosh, Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest, 2001. 107(1): p. 13-9.
May, M.J., et al., Selective inhibition of NF-kappaB activ ation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science, 2000. 289(5484): p. 1550-4.
Voll, R.E., et al., NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity, 2000. 13(5): p. 677-89.
Millet, I., et al., Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. J Biol Chem, 2000. 275(20): p. 15114-21.
Li, B., et al., Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science, 2000. 288(5474): p. 2219-22.
Fenwick, C., et al., A subclass of Ras proteins that regulate the degradation of IkappaB. Science, 2000. 287(5454): p. 869-73.
Budde, L.M. and S. Ghosh, Cloning and characterization of the gene encoding mouse IkappaBbeta. Gene, 2000. 247(1-2): p. 279-86.
Zhang, G. and S. Ghosh, Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J Endotoxin Res, 2000. 6(6): p. 453-7.
Wu, C. and S. Ghosh, beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. J Biol Chem, 1999. 274(42): p. 29591-4.
Kopp, E., et al., ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev, 1999. 13(16): p. 2059-71.
May, M.J. and S. Ghosh, IkappaB kinases: kinsmen with different crafts. Science, 1999. 284(5412): p. 271-3.
Ghosh, S., Regulation of inducible gene expression by the transcription fact or NF-kappaB. Immunol Res, 1999. 19(2-3): p. 183-9.
Voll, R.E. and S. Ghosh, Role of NF-kappa B in T-lymphocyte development. Cold Spring Harb Symp Quant Biol, 1999. 64: p. 485-90.
May, M.J. and S. Ghosh, Signal transduction through NF-kappa B. Immunol T oday, 1998. 19(2): p. 80-8.
Medzhitov, R., et al., MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell, 1998. 2(2): p. 253-8.
Zhong, H., R.E. Voll, and S. Ghosh, Phosphorylation of NF-kappa B p65 by PKA stimula tes transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell, 1998. 1(5): p. 661-71.
Ghosh, S., M.J. May, and E.B. Kopp, NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol, 1998. 16: p. 225-60.
Zhong, H., et al., The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell, 1997. 89(3): p. 413-24.
Phillips, R.J. and S. Ghosh, Regulation of IkappaB beta in WEHI 231 mature B cells. Mol Cell Biol, 1997. 17(8): p. 4390-6.
May, M.J. and S. Ghosh, Rel/NF-kappa B and I kappa B proteins: an overview. Semin Cancer Biol, 1997. 8(2): p. 63-73.
Suyang, H., et al., Role of un phosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B. Mol Cell Biol, 1996. 16(10): p. 5444-9.
Johnson, D.R., et al., A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human e ndothelial cells. J Biol Chem, 1996. 271(27): p. 16317-22.
Phillips, R.J., S. Gustafson, and S. Ghosh, Identification of a novel NF-kappaB p50-related protein in B lymphocytes. Mol Cell Biol, 1996. 16(12): p. 7089-97.
Ghosh, G., et al., Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature, 1995. 373(6512): p. 303-10.
Thompson, J.E., et al., I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell, 1995. 80(4): p. 573-82.
Kopp, E.B. and S. G hosh, NF-kappa B and rel proteins in innate immunity. Adv Immunol, 1995. 58: p. 1-27.
Kopp, E. and S. Ghosh, Inhibition of NF-kappa B by sodium salicylate and aspirin. Science, 1994. 265(5174): p. 956-9.
Ghosh, S., et al., Cloning of the p50 DNA bin ding subunit of NF-kappa B: homology to rel and dorsal. Cell, 1990. 62(5): p. 1019-29.
Ghosh, S. and D. Baltimore, Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature, 1990. 344(6267): p. 678-82.
India
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
n immunologist and microbiologist
Microbiologist
A microbiologist is a scientist who works in the field of microbiology. Microbiologists study organisms called microbes. Microbes can take the form of bacteria, viruses, fungi, and protists...
, who is the chair of the Department of Microbiology & Immunology at Columbia University Medical Center
Columbia University Medical Center
Columbia University Medical Center is an academic medical center that includes Columbia University's College of Physicians and Surgeons, College of Dental Medicine, School of Nursing and Mailman School of Public Health...
. Previously he has remained a Professor of Immunobiology, Molecular Biophysics
Molecular biophysics
Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology...
and Biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
, and Molecular
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
, Cellular
Cell biology
Cell biology is a scientific discipline that studies cells – their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division and death. This is done both on a microscopic and molecular level...
& Developmental Biology
Developmental biology
Developmental biology is the study of the process by which organisms grow and develop. Modern developmental biology studies the genetic control of cell growth, differentiation and "morphogenesis", which is the process that gives rise to tissues, organs and anatomy.- Related fields of study...
, and researcher working at Yale University
Yale University
Yale University is a private, Ivy League university located in New Haven, Connecticut, United States. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States...
for 17 years.
Sankar Ghosh's particular area of research is focused on the activation of cellular responses via the inducible transcription factor, NF-κB.
Education
Sankar Ghosh was born and brought up in Calcutta, now Kolkata, from where he did his B.Sc., M.Sc., Calcutta University, IndiaIndia
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
, 1981; M.S. Albert Einstein College of Medicine
Albert Einstein College of Medicine
Albert Einstein College of Medicine is a graduate school of Yeshiva University. It is a not-for-profit, private, nonsectarian medical school located on the Jack and Pearl Resnick Campus in the Morris Park neighborhood of the borough of the Bronx of New York City...
, New York
New York
New York is a state in the Northeastern region of the United States. It is the nation's third most populous state. New York is bordered by New Jersey and Pennsylvania to the south, and by Connecticut, Massachusetts and Vermont to the east...
(Yeshiva University
Yeshiva University
Yeshiva University is a private university in New York City, with six campuses in New York and one in Israel. Founded in 1886, it is a research university ranked as 45th in the US among national universities by U.S. News & World Report in 2012...
), 1984; He received his Ph.D.
Ph.D.
A Ph.D. is a Doctor of Philosophy, an academic degree.Ph.D. may also refer to:* Ph.D. , a 1980s British group*Piled Higher and Deeper, a web comic strip*PhD: Phantasy Degree, a Korean comic series* PhD Docbook renderer, an XML renderer...
, from Albert Einstein College of Medicine, New York, in 1988, and thereafter he did his postdoctoral work at the Whitehead Institute
Whitehead Institute
Founded in 1982, the Whitehead Institute for Biomedical Research is a non-profit research and teaching institution located in Cambridge, Massachusetts, USA....
, Cambridge, Massachusetts
Cambridge, Massachusetts
Cambridge is a city in Middlesex County, Massachusetts, United States, in the Greater Boston area. It was named in honor of the University of Cambridge in England, an important center of the Puritan theology embraced by the town's founders. Cambridge is home to two of the world's most prominent...
(MIT), under the supervision of Nobel laureate David Baltimore
David Baltimore
David Baltimore is an American biologist, university administrator, and Nobel laureate in Physiology or Medicine. He served as president of the California Institute of Technology from 1997 to 2006, and is currently the Robert A. Millikan Professor of Biology at Caltech...
(1989–1991).
Career
A Fellow of Irvington Institute for Medical Research; he joined Yale UniversityYale University
Yale University is a private, Ivy League university located in New Haven, Connecticut, United States. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States...
faculty, in 1991, and worked there for the next 17 year as Professor of Immunobiology; Molecular, Cellular, and Developmental Biology; and Molecular Biophysics and Biochemistry at Yale University School of Medicine, till he moved to Columbia University
Columbia University
Columbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the...
in 2008, where he became Chair Department of Microbiology at Columbia University Medical Center
Columbia University Medical Center
Columbia University Medical Center is an academic medical center that includes Columbia University's College of Physicians and Surgeons, College of Dental Medicine, School of Nursing and Mailman School of Public Health...
.
In 2002, he was named a Howard Hughes Medical Investigator by Howard Hughes Medical Institute
Howard Hughes Medical Institute
Howard Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...
. He was also awarded the Ranbaxy Science Foundation's Annual Research Awards for the year 2005, the foundation is a non-profit organization set-up by Ranbaxy Laboratories
Ranbaxy Laboratories
Ranbaxy Laboratories Limited is a pharmaceutical company that was incorporated in India in 1961. The company went public in 1973 and Japanese pharmaceutical company Daiichi Sankyo gained majority control in 2008...
Limited (RLL)., then in 2007 he was named as a Fellow of the AAAS
Fellow of the AAAS
Fellow of the AAAS is an honor accorded by the American Association for the Advancement of Science to distinguished persons who are members of the Association. Fellows are elected annually by the AAAS Council for "efforts on behalf of the advancement of science or its applications [which] are...
, by the American Association for the Advancement of Science
American Association for the Advancement of Science
The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
(AAAS), for "distinguished contributions to the field of immunology, particularly for studies of the NF-êB signaling pathway." .
Awards
2008 Frederick W. Alt Award for New Discoveries in Immunology - Canc er Research InstitutePublications
Shim, J.H., et al. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol. 2006 Mar 27.Shim, J.H., et al. TAK1, but not TAB1 or TA B2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005 Nov 15
Jimi, E. and S. Ghosh. Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev. 2005 Dec.
Jimi, E. et al. Activation of NF-{kappa}B promo tes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol. 20 May 2005
Bailey ST, Ghosh S. 'PPAR'ting ways with inflammation. Nat Immunol., 2005 Oct 6
E. C. Ziegler, S. Ghosh, Regulating Inducible Transcription Through Controlled Localization. Sci. STKE 2005, re6 (2005).
di Meglio, P., A. Ianaro, and S. Ghosh, Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum, 2005. 52(3): p. 951-8.
Lee, K.Y., et al., PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science, 2005. 308(5718): p. 114-8.
Hayden, M.S. and S. Ghosh, Signaling to NF-kappaB. Genes Dev, 2004. 18(18): p. 2195-224.
Zhang, D., et al., A toll-like receptor that prevents infection by uropathogenic bacteria. Science, 2004. 303(5663): p. 1522-6.
Jimi, E., et al., Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med, 2004. 10(6): p. 617-24.
Marienfeld, R., et al., RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem, 2003. 278(22): p. 19852-60.
Ma, X.Y., et al., The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem, 2003. 278(25): p. 23008-19.
Wu, C. and S. Ghosh, Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases. J Biol Chem, 2003. 278(34): p. 31980-7.
May, M.J., R.B. Marienfeld, and S. Ghosh, Characterization of the Ikappa B-kinase NEMO binding domain. J Biol Chem, 2002. 277(48): p. 45992-6000.
Zhang, G. and S. Ghosh, Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem, 2002. 277(9): p. 7059-65.
Zhong, H., et al., The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell, 2002. 9(3): p. 625-36.
D'Acquisto, F., M.J. May, and S. Ghosh, Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies. Mol Interv, 2002. 2(1): p. 22-35.
Budde, L.M., et al., Regulation of IkappaBbeta expression in testis. Mol Biol Cell, 2002. 13(12): p. 4179-94.
Ghosh, S. and M. Karin, Missing pieces in the NF-kappaB puzzle. Cell, 2002. 109 Suppl: p. S81-96.
D'Acquisto, F. and S. Ghosh, PACT and PKR: turning on NF-kappa B in the absence of virus. Sci STKE, 200 1. 2001(89): p. RE1.
Zhang, G. and S. Ghosh, Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest, 2001. 107(1): p. 13-9.
May, M.J., et al., Selective inhibition of NF-kappaB activ ation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science, 2000. 289(5484): p. 1550-4.
Voll, R.E., et al., NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity, 2000. 13(5): p. 677-89.
Millet, I., et al., Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. J Biol Chem, 2000. 275(20): p. 15114-21.
Li, B., et al., Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science, 2000. 288(5474): p. 2219-22.
Fenwick, C., et al., A subclass of Ras proteins that regulate the degradation of IkappaB. Science, 2000. 287(5454): p. 869-73.
Budde, L.M. and S. Ghosh, Cloning and characterization of the gene encoding mouse IkappaBbeta. Gene, 2000. 247(1-2): p. 279-86.
Zhang, G. and S. Ghosh, Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J Endotoxin Res, 2000. 6(6): p. 453-7.
Wu, C. and S. Ghosh, beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. J Biol Chem, 1999. 274(42): p. 29591-4.
Kopp, E., et al., ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev, 1999. 13(16): p. 2059-71.
May, M.J. and S. Ghosh, IkappaB kinases: kinsmen with different crafts. Science, 1999. 284(5412): p. 271-3.
Ghosh, S., Regulation of inducible gene expression by the transcription fact or NF-kappaB. Immunol Res, 1999. 19(2-3): p. 183-9.
Voll, R.E. and S. Ghosh, Role of NF-kappa B in T-lymphocyte development. Cold Spring Harb Symp Quant Biol, 1999. 64: p. 485-90.
May, M.J. and S. Ghosh, Signal transduction through NF-kappa B. Immunol T oday, 1998. 19(2): p. 80-8.
Medzhitov, R., et al., MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell, 1998. 2(2): p. 253-8.
Zhong, H., R.E. Voll, and S. Ghosh, Phosphorylation of NF-kappa B p65 by PKA stimula tes transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell, 1998. 1(5): p. 661-71.
Ghosh, S., M.J. May, and E.B. Kopp, NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol, 1998. 16: p. 225-60.
Zhong, H., et al., The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell, 1997. 89(3): p. 413-24.
Phillips, R.J. and S. Ghosh, Regulation of IkappaB beta in WEHI 231 mature B cells. Mol Cell Biol, 1997. 17(8): p. 4390-6.
May, M.J. and S. Ghosh, Rel/NF-kappa B and I kappa B proteins: an overview. Semin Cancer Biol, 1997. 8(2): p. 63-73.
Suyang, H., et al., Role of un phosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B. Mol Cell Biol, 1996. 16(10): p. 5444-9.
Johnson, D.R., et al., A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human e ndothelial cells. J Biol Chem, 1996. 271(27): p. 16317-22.
Phillips, R.J., S. Gustafson, and S. Ghosh, Identification of a novel NF-kappaB p50-related protein in B lymphocytes. Mol Cell Biol, 1996. 16(12): p. 7089-97.
Ghosh, G., et al., Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature, 1995. 373(6512): p. 303-10.
Thompson, J.E., et al., I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell, 1995. 80(4): p. 573-82.
Kopp, E.B. and S. G hosh, NF-kappa B and rel proteins in innate immunity. Adv Immunol, 1995. 58: p. 1-27.
Kopp, E. and S. Ghosh, Inhibition of NF-kappa B by sodium salicylate and aspirin. Science, 1994. 265(5174): p. 956-9.
Ghosh, S., et al., Cloning of the p50 DNA bin ding subunit of NF-kappa B: homology to rel and dorsal. Cell, 1990. 62(5): p. 1019-29.
Ghosh, S. and D. Baltimore, Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature, 1990. 344(6267): p. 678-82.
External links
- Research Abstract: Mechanisms Regulating the Biological Activity of the Transcription Factor NFκB by Sankar Ghosh at HHMIHoward Hughes Medical InstituteHoward Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...