San Francisco, California
San Francisco (ˌ), officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area
San Francisco Bay Area
The San Francisco Bay Area, commonly known as the Bay Area, is a populated region that surrounds the San Francisco and San Pablo estuaries in Northern California. The region encompasses metropolitan areas of San Francisco, Oakland, and San Jose, along with smaller urban and rural areas...

, a region of 7.15 million people which includes San Jose
San Jose, California
San Jose is the third-largest city in California, the tenth-largest in the U.S., and the county seat of Santa Clara County which is located at the southern end of San Francisco Bay...

 and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121.5 km²) on the northern end of the San Francisco Peninsula
San Francisco Peninsula
The San Francisco Peninsula is a peninsula in the San Francisco Bay Area that separates the San Francisco Bay from the Pacific Ocean. On its northern tip is the City and County of San Francisco. Its southern base is in Santa Clara County, including the cities of Palo Alto, Los Altos, and Mountain...

, giving it a density of about 17,179 people per square mile (6,632 people per km2).

1776    Father Francisco Palou founds Mission San Francisco de Asis in what is now San Francisco, California.

1847    Yerba Buena, California is renamed San Francisco.

1848    California Gold Rush: The first ship with Chinese immigrants arrives in San Francisco, California.

1852    Congress establishes the United States' 2nd mint in San Francisco, California.

1873    The University of California opens its first medical school in San Francisco, California.

1876    An express train called the ''Transcontinental Express'' arrives in San Francisco, California, via the First Transcontinental Railroad only 83 hours and 39 minutes after leaving New York City.

1892    In San Francisco, California, John Muir organizes the Sierra Club.

1906    San Francisco public school board sparks United States diplomatic crisis with Japan by ordering Japanese students to be taught in racially segregated schools.

1907    Bubonic plague breaks out in San Francisco, California.

1916    In San Francisco, California, a bomb explodes on Market Street during a Preparedness Day parade killing 10 and injuring 40.