STR multiplex systems
Encyclopedia
An STR multiplex system is used to quickly identify specific short tandem repeat
s. STR polymorphism
s are genetic marker
s that may be used to identify a DNA sequence
.
The FBI uses 13 specific STR loci in their database. These may be used in many areas of genetics in addition to their legal uses.
One can think of a STR Multiplex System as collection of certain specific STRs which are positionally conserved on a target genome.
Hence these can be used as markers. A number of different STRs along with their loci in a particular genome can be used for genotyping
.
As for example the STR Multiplex System "AmpFlSTR Profiler Plus " (contain these STRs :D3S1358, VWA, FGA, Amelogenin, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, and they can be used as markers for human genome) is used for human identification purpose.
Short tandem repeat
A short tandem repeat in DNA occurs when a pattern of two or more nucleotides are repeated and the repeated sequences are directly adjacent to each other. The pattern can range in length from 2 to 5 base pairs and is typically in the non-coding intron region...
s. STR polymorphism
Polymorphism (biology)
Polymorphism in biology occurs when two or more clearly different phenotypes exist in the same population of a species — in other words, the occurrence of more than one form or morph...
s are genetic marker
Genetic marker
A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify cells, individuals or species. It can be described as a variation that can be observed...
s that may be used to identify a DNA sequence
DNA sequence
The sequence or primary structure of a nucleic acid is the composition of atoms that make up the nucleic acid and the chemical bonds that bond those atoms. Because nucleic acids, such as DNA and RNA, are unbranched polymers, this specification is equivalent to specifying the sequence of...
.
The FBI uses 13 specific STR loci in their database. These may be used in many areas of genetics in addition to their legal uses.
One can think of a STR Multiplex System as collection of certain specific STRs which are positionally conserved on a target genome.
Hence these can be used as markers. A number of different STRs along with their loci in a particular genome can be used for genotyping
Genotyping
Genotyping is the process of determining differences in the genetic make-up of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence. It reveals the alleles an individual has inherited from their...
.
As for example the STR Multiplex System "AmpFlSTR Profiler Plus " (contain these STRs :D3S1358, VWA, FGA, Amelogenin, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, and they can be used as markers for human genome) is used for human identification purpose.