SRA1
Encyclopedia
Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein
that in humans is encoded by the SRA1 gene
. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1
. This functional RNA also encodes a protein.
by steroid receptor
. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.
with:
The SRAP has been shown to interact with its SRA RNA counterpart via its RRM-like domain interacting with the functional sub-structure STR7 of SRA RNA.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SRA1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1
Nuclear receptor coactivator 1
The nuclear receptor coactivator 1 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity . NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates...
. This functional RNA also encodes a protein.
Function
This gene is involved in transcriptional coactivationCoactivation (Transcription)
Coactivation is a process by which the transcription of RNA is increased. Proteins called coactivators are recruited to DNA-binding transcription factors through their activation domains and increase transcription by relaxing the chromatin structure to allow greater access to a gene or by bringing...
by steroid receptor
Steroid hormone receptor
Steroid hormone receptors are found on the plasma membrane, in the cytosol and also in the nucleus of target cells. They are generally intracellular receptors and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days...
. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.
Interactions
SRA1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with:
- Estrogen receptor alphaEstrogen receptor alphaEstrogen receptor alpha , also known as NR3A1 , is a nuclear receptor that is activated by the sex hormone estrogen...
, - DDX17DDX17Probable ATP-dependent RNA helicase DDX17 is an enzyme that in humans is encoded by the DDX17 gene.-Interactions:DDX17 has been shown to interact with HDAC1, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Estrogen receptor alpha, Nuclear receptor coactivator 2, SRA1,, DDX5 and...
, - Nuclear receptor coactivator 2Nuclear receptor coactivator 2The nuclear receptor coactivator 2 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA2 in turn acylates...
, and - SPENSPENMsx2-interacting protein is a protein that in humans is encoded by the SPEN gene.-Interactions:SPEN has been shown to interact with HDAC1, SRA1 and Nuclear receptor co-repressor 2.-Further reading:...
.
The SRAP has been shown to interact with its SRA RNA counterpart via its RRM-like domain interacting with the functional sub-structure STR7 of SRA RNA.