The nuclear receptor coactivator 2 is a transcriptional coregulatory

Transcription coregulator

In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes. Transcription coregulators that activate gene transcription are referred to as coactivators while those that...

 protein which contains several nuclear receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...

 interacting domains and an intrinsic histone acetyltransferase

Histone acetyltransferase

Histone acetyltransferases are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine....

 activity. NCOA2 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA2 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA2 assists nuclear receptors in the upregulation of DNA expression.

NCOA2 is also frequently called glucocorticoid receptor interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Interactions

Nuclear receptor coactivator 2 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with DDX17

DDX17

Probable ATP-dependent RNA helicase DDX17 is an enzyme that in humans is encoded by the DDX17 gene.-Interactions:DDX17 has been shown to interact with HDAC1, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Estrogen receptor alpha, Nuclear receptor coactivator 2, SRA1,, DDX5 and...

, Androgen receptor

Androgen receptor

The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...

, Glucocorticoid receptor

Glucocorticoid receptor

The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....

, BRCA1

BRCA1

BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...

, Peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma , also known as the glitazone receptor, or NR1C3 is a type II nuclear receptor that in humans is encoded by the PPARG gene.Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 and...

, Aryl hydrocarbon receptor nuclear translocator

Aryl hydrocarbon receptor nuclear translocator

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor , and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor,...

, Estrogen receptor alpha

Estrogen receptor alpha

Estrogen receptor alpha , also known as NR3A1 , is a nuclear receptor that is activated by the sex hormone estrogen...

, PPFIA4

PPFIA4

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.-Interactions:PPFIA4 has been shown to interact with ERC2, GIT1 and Nuclear receptor coactivator 2.-Further reading:...

, DDX5

DDX5

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.- Function :...

, Calcitriol receptor

Calcitriol receptor

The calcitriol receptor, also known as the vitamin D receptor and also known as NR1I1 , is a member of the nuclear receptor family of transcription factors...

, SRA1

SRA1

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1...

 and Retinoid X receptor alpha

Retinoid X receptor alpha

Retinoid X receptor alpha , also known as NR2B1 is a nuclear receptor that in humans is encoded by the RXRA gene.- Function :...

.

Further reading