SKP1A
Encyclopedia
S-phase kinase-associated protein 1 is an enzyme
that in humans is encoded by the SKP1 gene
.
This gene encodes a protein
that is a member of the SCF
ubiquitin ligase
protein complex
. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2
, and other regulatory proteins involved in ubiquitin
dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing
of this gene results in two transcript variants. A related pseudogene
has been identified on chromosome 7.
with FBXL3
, FBXO5
, FBXO4
, FBXO7
, SKP2
, CDK9
, CUL1
, CDCA3
, CACYBP
, BTRC
, FBXW2
and FBXW7
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the SKP1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene encodes a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that is a member of the SCF
SCF complex
Skp, Cullin, F-box containing complex is a multi-protein E3 ubiquitin ligase complex catalyzing the ubiquitination of proteins destined for proteasomal degradation...
ubiquitin ligase
Ubiquitin ligase
A ubiquitin ligase is a protein that in combination with an E2 ubiquitin-conjugating enzyme causes the attachment of ubiquitin to a lysine on a target protein via an isopeptide bond; the E3 ubiquitin ligase targets specific protein substrates for degradation by the proteasome...
protein complex
Protein complex
A multiprotein complex is a group of two or more associated polypeptide chains. If the different polypeptide chains contain different protein domain, the resulting multiprotein complex can have multiple catalytic functions...
. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2
SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.- Function :This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box domain...
, and other regulatory proteins involved in ubiquitin
Ubiquitin
Ubiquitin is a small regulatory protein that has been found in almost all tissues of eukaryotic organisms. Among other functions, it directs protein recycling.Ubiquitin can be attached to proteins and label them for destruction...
dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing
Alternative splicing
Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing...
of this gene results in two transcript variants. A related pseudogene
Pseudogene
Pseudogenes are dysfunctional relatives of known genes that have lost their protein-coding ability or are otherwise no longer expressed in the cell...
has been identified on chromosome 7.
Interactions
SKP1A has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with FBXL3
FBXL3
F-box/LRR-repeat protein 3 is a protein that in humans is encoded by the FBXL3 gene.-Further reading:...
, FBXO5
FBXO5
F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.-Interactions:FBXO5 has been shown to interact with SKP1A, FZR1 and CDC20.-Further reading:...
, FBXO4
FBXO4
F-box only protein 4 is a protein that in humans is encoded by the FBXO4 gene.-Interactions:FBXO4 has been shown to interact with SKP1A and CUL1.-Further reading:...
, FBXO7
FBXO7
F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene.-Interactions:FBXO7 has been shown to interact with SKP1A and CUL1.-Further reading:...
, SKP2
SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.- Function :This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box domain...
, CDK9
CDK9
CDK9 or cyclin-dependent kinase 9 is a cyclin-dependent kinase associated with P-TEFb.CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle...
, CUL1
CUL1
Cullin 1, also known as CUL1, is a human protein and gene from cullin family.This protein plays an important role in protein degradation and protein ubiquitination....
, CDCA3
CDCA3
Cell division cycle-associated protein 3 is a protein that in humans is encoded by the CDCA3 gene.-Further reading:...
, CACYBP
CACYBP
Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.-Interactions:CACYBP has been shown to interact with SKP1A and SIAH1.-Further reading:...
, BTRC
BTRC (gene)
F-box/WD repeat-containing protein 1A also known as βTrCP1 or Fbxw1 or hsSlimb or pIkappaBalpha-E3 receptor subunit is a protein that in humans is encoded by the BTRC gene....
, FBXW2
FBXW2
F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.-Further reading:...
and FBXW7
FBXW7
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene.-Interactions:FBXW7 has been shown to interact with PPARGC1A, Parkin , MYB and SKP1A.-Further reading:...
.