Rs1805054
Encyclopedia
In genetics
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....

, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism
Single nucleotide polymorphism
A single-nucleotide polymorphism is a DNA sequence variation occurring when a single nucleotide — A, T, C or G — in the genome differs between members of a biological species or paired chromosomes in an individual...

 (SNP), in the HTR6 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.
It is one of the few investigated polymorphisms of its gene.
C267T is a synonymous polymorphism.

As of 2008 meta-analysis
Meta-analysis
In statistics, a meta-analysis combines the results of several studies that address a set of related research hypotheses. In its simplest form, this is normally by identification of a common measure of effect size, for which a weighted average might be the output of a meta-analyses. Here the...

 of the polymorphism and Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...

 indicates that there probably is no association between the two,
though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease.
Another reported association in neuropsychiatry disorders is with treatment response in depression.

C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait self-transcendence.
A Japanese study reported no association with personality traits using the NEO PI-R personality inventory.
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