Rolitetracycline
Encyclopedia
Rolitetracycline is a tetracycline antibiotic. Tetracycline is N-Mannich base
prodrug
that is prepared from tetracycline by condensation with pyrrolidine
and formaldehyde
to produce rolitetracycline.
Mannich base
A mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde and a carbon acid . The Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary amine to produce...
prodrug
Prodrug
A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...
that is prepared from tetracycline by condensation with pyrrolidine
Pyrrolidine
Pyrrolidine, also known as tetrahydropyrrole, is an organic compound with the molecular formula C4H9N. It is a cyclic secondary amine with a five-membered heterocycle containing four carbon atoms and one nitrogen atom...
and formaldehyde
Formaldehyde
Formaldehyde is an organic compound with the formula CH2O. It is the simplest aldehyde, hence its systematic name methanal.Formaldehyde is a colorless gas with a characteristic pungent odor. It is an important precursor to many other chemical compounds, especially for polymers...
to produce rolitetracycline.