Relaxin receptor
Encyclopedia
The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin
peptide hormones.
Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.
Relaxin
Relaxin is a protein hormone first described in 1926 by Frederick Hisaw.The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 , 2 and 3 , and the insulin-like peptides, INSL3, INSL4, INSL5 and INSL6...
peptide hormones.
Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits |
|---|---|---|---|
| Relaxin Relaxin Relaxin is a protein hormone first described in 1926 by Frederick Hisaw.The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 , 2 and 3 , and the insulin-like peptides, INSL3, INSL4, INSL5 and INSL6... 1, Relaxin 2, Relaxin 3 |
adenylate cyclase Adenylate cyclase Adenylate cyclase is part of the G protein signalling cascade, which transmits chemical signals from outside the cell across the membrane to the inside of the cell .... , protein kinase A, protein kinase C Protein kinase C Protein kinase C also known as PKC is a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in... , phosphatidylinositol 3-kinase, extracellular signal-regulated kinases Extracellular signal-regulated kinases In molecular biology, extracellular-signal-regulated kinases or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells... (Erk1/2) |
||
| Relaxin 1, Relaxin 2, | adenylate cyclase | ||
| Relaxin 3 | Erk1/2 signaling | adenylate cyclase | |
| Relaxin 3, | adenylate cyclase |