Rh family, B glycoprotein, also known as RHBG, is an ammonia transporter

Ammonia transporter

Ammonia transporters are structurally related membrane transport proteins called Amt proteins , methylammonium/ammonium permeases or RhAG, RhBG, and RhCG Rh family members in mammals. The RhAG, RhBG and RhCG proteins constitute solute carrier family 42...

 protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which in humans is encoded by the RHBG gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein

Rhesus blood group system

The Rh blood group system is one of thirty current human blood group systems. Clinically, it is the most important blood group system after ABO. At Present, the Rh blood group system consists of 50 defined blood-group antigens, among which the 5 antigens D, C, c, E, and e are the most important...

 family that are mainly expressed in the kidney

Kidney

The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...

 and belong to the methylammonium-ammonium permease/ammonia transporter

Ammonia transporter

Ammonia transporters are structurally related membrane transport proteins called Amt proteins , methylammonium/ammonium permeases or RhAG, RhBG, and RhCG Rh family members in mammals. The RhAG, RhBG and RhCG proteins constitute solute carrier family 42...

s superfamily. Rh family proteins are all predicted to be transmembrane protein

Transmembrane protein

A transmembrane protein is a protein that goes from one side of a membrane through to the other side of the membrane. Many TPs function as gateways or "loading docks" to deny or permit the transport of specific substances across the biological membrane, to get into the cell, or out of the cell as...

s with 12 membrane spanning domains and intracytoplasmic N- and C-termini.

Further reading