RACK is an acronym for Receptor for Activated C-Kinase and is responsible for the binding of active forms of the protein kinase

Protein kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins...

 C (PKC) family of enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

s. See also RICK protein, Receptor for Inactive C-Kinase.

There are different RACKs for different isoforms of PKC, which thus mediate differential subcellular targeting of the isoforms.

Inactive forms of PKC occlude the RACK binding site with a pseudo-RACK peptide sequence

RACKs share 47% identity with the beta subunit of G proteins

RACKs represent one of the many ways in which a cell can use signalling complexes to manipulate the specificity of interactions within intracellular signalling cascades