Propanidid
Encyclopedia
Propanidid is an ultra short-acting phenylacetate general anesthetic. It was originally introduced by Bayer
in 1963 but anaphylactic reactions caused it to be withdrawn shortly afterwards.
Even though Cremophor EL
has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to Propanidid (and Althesin
) were due to the drugs themselves . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.
Bayer
Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:...
in 1963 but anaphylactic reactions caused it to be withdrawn shortly afterwards.
Even though Cremophor EL
Cremophor EL
Cremophor EL is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil. It is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil...
has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to Propanidid (and Althesin
Althesin
Alfaxolone/alfadolone is a short acting intravenous anaesthetic agent, now withdrawn from the market due to severe drug reactions. It is composed of a mixture of alfaxalone and alfadolone, two neurosteroids.Cremophor EL Alfaxolone/alfadolone (Althesin) is a short acting intravenous anaesthetic...
) were due to the drugs themselves . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.