Althesin
Encyclopedia
Alfaxolone/alfadolone is a short acting intravenous anaesthetic agent, now withdrawn from the market due to severe drug reactions. It is composed of a mixture of alfaxalone
and alfadolone
, two neurosteroids.
Cremophor EL
(aka. Polyoxyl 35 Castor Oil, a surfactant and derivative of castor oil) was the solubilizing agent (excipient / additive) of Althesin.
A study 2001 found that Cremophor EL , when previously used as a solubilizing agent in lipid emulsions, was responsible for severe anaphylactoid reactions. Drugs using it were reformulated to use other emulsifiers.
Alfaxolone/alfadolone has been re-branded as "Saffan" and is available for use in veterinary anaesthesia.
Alfaxalone
Alfaxalone is a neurosteroid general anaesthetic.It is one of the constituents of althesin.It is used in veterinary practice under the tradename Alfaxan....
and alfadolone
Alfadolone
Alfadolone or alphadolone is a neuroactive steroid with hypnotic effects. It is one of the components of althesin....
, two neurosteroids.
Cremophor EL
Cremophor EL
Cremophor EL is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil. It is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil...
(aka. Polyoxyl 35 Castor Oil, a surfactant and derivative of castor oil) was the solubilizing agent (excipient / additive) of Althesin.
A study 2001 found that Cremophor EL , when previously used as a solubilizing agent in lipid emulsions, was responsible for severe anaphylactoid reactions. Drugs using it were reformulated to use other emulsifiers.
Alfaxolone/alfadolone has been re-branded as "Saffan" and is available for use in veterinary anaesthesia.