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Plasmacytoma
 
 
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Plasmacytoma refers to a malignant
Malignant

Malignant is a medical term used to describe a severe and progressively worsening disease. The term is most familiar as a description of cancer....
 plasma cell
Plasma cell

Plasma cells, also called plasma B cells or plasmocytes, are White blood cells of the immune system transported by the blood plasma and the lymphatic system....
 tumor
Tumor

A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells . Tumor is not synonymous with cancer. A tumor can be Benign neoplasm, Carcinoma in situ or malignant, whereas cancer is by definition malignant....
 growing within soft tissue
Soft tissue

In medicine, the term soft tissue refers to Tissue that connect, support, or surround other structures and Organ s of the body.Soft tissue includes tendons, ligaments, fascia, Fibrous connective tissue, fat, and synovial membranes , and muscles, nerves and blood vessels ....
. It is similar to multiple myeloma
Multiple myeloma

Multiple myeloma is a cancer of plasma cells. These immune system cells are formed in bone marrow, are numerous in lymphatics and produce antibody....
, but lacks the bone changes and resultant hypercalcemia seen in multiple myeloma.

e can be some ambiguity when using the word.

"Plasmacytoma" is sometimes equated with "plasma cell dyscrasia" or "solitary myeloma".

It is often used as part of the phrase "solitary plasmacytoma".

It is also used as part of the phrase "extramedullary plasmacytoma ".






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Encyclopedia


Plasmacytoma refers to a malignant
Malignant

Malignant is a medical term used to describe a severe and progressively worsening disease. The term is most familiar as a description of cancer....
 plasma cell
Plasma cell

Plasma cells, also called plasma B cells or plasmocytes, are White blood cells of the immune system transported by the blood plasma and the lymphatic system....
 tumor
Tumor

A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells . Tumor is not synonymous with cancer. A tumor can be Benign neoplasm, Carcinoma in situ or malignant, whereas cancer is by definition malignant....
 growing within soft tissue
Soft tissue

In medicine, the term soft tissue refers to Tissue that connect, support, or surround other structures and Organ s of the body.Soft tissue includes tendons, ligaments, fascia, Fibrous connective tissue, fat, and synovial membranes , and muscles, nerves and blood vessels ....
. It is similar to multiple myeloma
Multiple myeloma

Multiple myeloma is a cancer of plasma cells. These immune system cells are formed in bone marrow, are numerous in lymphatics and produce antibody....
, but lacks the bone changes and resultant hypercalcemia seen in multiple myeloma.

Terminology

There can be some ambiguity when using the word.

"Plasmacytoma" is sometimes equated with "plasma cell dyscrasia" or "solitary myeloma".

It is often used as part of the phrase "solitary plasmacytoma".

It is also used as part of the phrase "extramedullary plasmacytoma ". In this context, "extramedullary" means outside of the bone marrow
Bone marrow

Bone marrow is the flexible biological tissue found in the hollow interior of bones. In adults, marrow in large bones produces new blood cells....
.

Diagnosis

It is diagnosed by immunoglobulin electrophoresis (or Serum protein electrophoresis
Serum protein electrophoresis

Serum protein electrophoresis is a laboratory test that examines specific proteins in the blood called globulins. Blood must first be collected, usually into an airtight vial or syringe....
) and bone marrow biopsy
Bone marrow biopsy

Bone marrow examination refers to the pathology analysis of samples of bone marrow obtained by bone marrow biopsy and bone marrow aspiration....
. Immunoglobulin electrophoresis will show a monoclonal M spike, but bone marrow biopsy will fail to find the classical signs of multiple myeloma
Multiple myeloma

Multiple myeloma is a cancer of plasma cells. These immune system cells are formed in bone marrow, are numerous in lymphatics and produce antibody....
. After those two determinations are made, search for the primary site in the soft tissue begins.

See also

  • Waldenstrom's macroglobulinemia
  • Monoclonal gammopathy of undetermined significance
    Monoclonal gammopathy of undetermined significance

    Monoclonal gammopathy of undetermined significance or benign monoclonal gammopathy is a condition in which a low or non-quantifiable level of a monoclonal paraprotein is detected in the blood by means of protein electrophoresis....
     or MGUS


External links

  • at National Cancer Institute
    National Cancer Institute

    The National Cancer Institute is part of the United States Federal government's National Institutes of Health. The NCI is a federally funded research and development center, one of eight agencies that compose the United States Public Health Service in the United States Department of Health and Human Services....