Nucleoporin
Encyclopedia
The nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore
complex. The nuclear pore
complex is a massive structure that extends across the nuclear envelope
, forming a gateway that regulates the flow of macromolecules between the cell nucleus
and the cytoplasm
. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore
complex in eukaryotic cells. Nuclear pores in turn allow the transport of water-soluble molecules across the nuclear envelope
.
The proteins involved are named for their molecular weight (in kilo Daltons
), and include the following:
Nuclear pore
Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about on average 2000 nuclear pore complexes in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in...
complex. The nuclear pore
Nuclear pore
Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about on average 2000 nuclear pore complexes in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in...
complex is a massive structure that extends across the nuclear envelope
Nuclear envelope
A nuclear envelope is a double lipid bilayer that encloses the genetic material in eukaryotic cells. The nuclear envelope also serves as the physical barrier, separating the contents of the nucleus from the cytosol...
, forming a gateway that regulates the flow of macromolecules between the cell nucleus
Cell nucleus
In cell biology, the nucleus is a membrane-enclosed organelle found in eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these...
and the cytoplasm
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore
Nuclear pore
Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about on average 2000 nuclear pore complexes in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in...
complex in eukaryotic cells. Nuclear pores in turn allow the transport of water-soluble molecules across the nuclear envelope
Nuclear envelope
A nuclear envelope is a double lipid bilayer that encloses the genetic material in eukaryotic cells. The nuclear envelope also serves as the physical barrier, separating the contents of the nucleus from the cytosol...
.
The proteins involved are named for their molecular weight (in kilo Daltons
Atomic mass unit
The unified atomic mass unit or dalton is a unit that is used for indicating mass on an atomic or molecular scale. It is defined as one twelfth of the rest mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state, and has a value of...
), and include the following:
- NUP35NUP35Nucleoporin NUP35 is a protein that in humans is encoded by the NUP35 gene.-Further reading:...
, NUP37NUP37Nucleoporin 37kDa, also known as NUP37, is a human gene.- Function :Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP37 is part of one such subcomplex, Nup107-160....
, NUP43NUP43Nucleoporin Nup43 is a protein that in humans is encoded by the NUP43 gene.-Further reading:...
, NUP50NUP50Nucleoporin 50 kDa is a protein that in humans is encoded by the NUP50 gene.-Interactions:NUP50 has been shown to interact with KPNB1 and CDKN1B.-Further reading:... - NUP54NUP54Nucleoporin p54 is a protein that in humans is encoded by the NUP54 gene.-Further reading:...
, NUP62, NUP85NUP85Nucleoporin NUP85 is a protein that in humans is encoded by the NUP85 gene.-Further reading:...
, NUP88NUP88Nuclear pore complex protein Nup88 is a protein that in humans is encoded by the NUP88 gene.-Further reading:...
, NUP93NUP93Nuclear pore complex protein Nup93 is a protein that in humans is encoded by the NUP93 gene.-Further reading:...
, NUP98NUP98Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.-Interactions:NUP98 has been shown to interact with NUP88, KPNB1, RAE1, CREB-binding protein and TNPO2.-Further reading:... - NUP107NUP107Nuclear pore complex protein Nup107 is a protein that in humans is encoded by the NUP107 gene.-Further reading:...
, NUP133NUP133Nuclear pore complex protein Nup133 is a protein that in humans is encoded by the NUP133 gene.-Further reading:...
, NUP153NUP153NUP153, is a human gene that codes for the 153 kDa protein Nucleoporin 153kDa.-Interactions:NUP153 has been shown to interact with SENP2 and KPNB1.-Further reading:...
, NUP155NUP155Nuclear pore complex protein Nup155 is a protein that in humans is encoded by the NUP155 gene.-Further reading:...
, NUP160NUP160Nuclear pore complex protein Nup160 is a protein that in humans is encoded by the NUP160 gene.-Further reading:...
, NUP188NUP188Nucleoporin 188kDa, also known as NUP188, is a human gene.- Function :Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP188 is part of one such subcomplex.... - NUP205NUP205Nuclear pore complex protein Nup205 also known as nucleoporin 205kDa is a protein that in humans is encoded by the NUP205 gene.- Function :...
, NUP210Nucleoporin 210kDaNuclear pore glycoprotein-210 is an essential trafficking regulator in the eukaryotic nuclear pore complex. Gp-210 anchors the pore complex to the nuclear membrane...
, NUP214NUP214Nuclear pore complex protein Nup214 is a protein that in humans is encoded by the NUP214 gene.The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are...