Description

• Environmental reservoir: soil and water.

• Smooth and nonpigmented colonies, growth below the surface of semisolid agar medium after deep inoculation (as seen with M. bovis
  Mycobacterium bovis
  Mycobacterium bovis is a slow-growing , aerobic bacterium and the causative agent of tuberculosis in cattle...
  
  ), 0.9 - 1.7mm in diameter.

• Growth on inspissated egg medium and oleic acid-albumin agar at a temperature range of 22°C-37°C requires over 1 week.
• Susceptible to ethambutol
  Ethambutol
  Ethambutol is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin and pyrazinamide....
  
  , ethionamide
  Ethionamide
  Ethionamide is an antibiotic used in the treatment of tuberculosis.It is a prodrug.It has been proposed for use in combination with gatifloxacin.The action may be through disruption of mycolic acid.-Synthesis:...
  
  , kanamycin
  Kanamycin
  Kanamycin sulfate is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from Streptomyces kanamyceticus.-Mechanism:...
  
   and cycloserine
  Cycloserine
  Cycloserine is an antibiotic effective against Mycobacterium tuberculosis. For the treatment of tuberculosis, it is classified as a second line drug, i.e...
  
  .

• Antigenic structure: seroagglutination demonstrates a single serovar distinct from that of other species.

Pathogenesis

• Usually infects young children with cervical lymphadenitis or adults with chronic pulmonary disease, (mostly with previously documented pneumoconiosis
  Pneumoconiosis
  Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation of dust, often in mines.-Types:Depending upon the type of dust, the disease is given different names:...
  
  ).
• Rarely causes extrapulmonary diseases and disseminated infections
• Biosafety level
  Biosafety level
  A biosafety level is the level of the biocontainment precautions required to isolate dangerous biological agents in an enclosed facility. The levels of containment range from the lowest biosafety level 1 to the highest at level 4 . In the United States, the Centers for Disease Control and...
  
   2

Type strain

• First isolated from sputum
  Sputum
  Sputum is mucus that is coughed up from the lower airways. It is usually used for microbiological investigations of respiratory infections....
  
   and biopsy
  Biopsy
  A biopsy is a medical test involving sampling of cells or tissues for examination. It is the medical removal of tissue from a living subject to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically...
  
   specimens with pulmonary disease in Malmö, Sweden
  Sweden
  Sweden , officially the Kingdom of Sweden , is a Nordic country on the Scandinavian Peninsula in Northern Europe. Sweden borders with Norway and Finland and is connected to Denmark by a bridge-tunnel across the Öresund....
  
  .