Muscarinic toxin 7
Encyclopedia
Muscarinic toxin 7 is part of a family of small peptides of 64 to 66 amino acid
residues
derived from the venom of African mamba
snakes (Dendroaspis angusticeps and Dendroaspis polylepis), which target the different muscarinic receptor subtypes. Muscarinic toxins like the nicotinic toxins have the three-finger fold structure, characteristic of the large superfamily of toxins that act at cholinergic synapses.
MT7 is likely to bind to the human M1 receptor in its dimer form with the tips of MT7 loops II and III contacting one hM1 protomer and the tip of loop I binds to the other protomer.
Amino acid
Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
residues
derived from the venom of African mamba
Mamba
Mambas, of the genus Dendroaspis , are a group of highly venomous, fast-moving land-dwelling snakes of Africa. They belong to the family of Elapidae which includes cobras, coral snakes, taipans, brown snakes, tiger snakes, death adders, kraits and, debatably, sea snakes...
snakes (Dendroaspis angusticeps and Dendroaspis polylepis), which target the different muscarinic receptor subtypes. Muscarinic toxins like the nicotinic toxins have the three-finger fold structure, characteristic of the large superfamily of toxins that act at cholinergic synapses.
MT7 is likely to bind to the human M1 receptor in its dimer form with the tips of MT7 loops II and III contacting one hM1 protomer and the tip of loop I binds to the other protomer.