Mometasone furoate
Encyclopedia
Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation
of the skin
or in the airway
s.
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema
and psoriasis
), allergic rhinitis
(such as hay fever
), asthma
for patients unresponsive to less potent corticosteroids, and penile phimosis
. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone
.
It reduces inflammation by causing several effects:
markets the medication under the following brand names; Elocon (Elocom, Elomet, Elosalic) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI)
for lower respiratory conditions.
Essex pharma markets the medication under the brand name Ecural and Progreś Laboratories markets it under mometAid.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa
under the brand name Mometamax.
Inflammation
Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...
of the skin
Skin
-Dermis:The dermis is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and strain. The dermis is tightly connected to the epidermis by a basement membrane. It also harbors many Mechanoreceptors that provide the sense of touch and heat...
or in the airway
Airway
The pulmonary airway comprises those parts of the respiratory system through which air flows, conceptually beginning at the nose and mouth, and terminating in the alveoli...
s.
Uses, administration, and pharmacodynamics
Eczema
Eczema is a form of dermatitis, or inflammation of the epidermis . In England, an estimated 5.7 million or about one in every nine people have been diagnosed with the disease by a clinician at some point in their lives.The term eczema is broadly applied to a range of persistent skin conditions...
and psoriasis
Psoriasis
Psoriasis is an autoimmune disease that appears on the skin. It occurs when the immune system mistakes the skin cells as a pathogen, and sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis is not contagious. However, psoriasis has been linked to an increased risk of...
), allergic rhinitis
Allergic rhinitis
Allergic rhinitis, also known as pollenosis or hay fever, is an allergic inflammation of the nasal airways.It occurs when an allergen, such as pollen, dust or animal dander is inhaled by an individual with a sensitized immune system...
(such as hay fever
Hay Fever
Hay Fever is a comic play written by Noël Coward in 1924 and first produced in 1925 with Marie Tempest as the first Judith Bliss. Laura Hope Crews played the role in New York...
), asthma
Asthma
Asthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include wheezing, coughing, chest tightness, and shortness of breath...
for patients unresponsive to less potent corticosteroids, and penile phimosis
Phimosis
Phimosis , from the Greek phimos ), is a condition where, in men, the foreskin cannot be fully retracted over the glans penis...
. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone
Dexamethasone
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant...
.
It reduces inflammation by causing several effects:
- reversing the activation of inflammatory proteins
- activating the secretion of anti-inflammatory proteins
- stabilising cell membranes
- decreasing the influx of inflammatory cells
- the exact anti-inflammatory mechanism of action is unknown
Availability
Schering-PloughSchering-Plough
Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...
markets the medication under the following brand names; Elocon (Elocom, Elomet, Elosalic) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI)
Dry powder inhaler
A Dry powder inhaler is a device that delivers medication to the lungs in the form of a dry powder. DPIs are commonly used to treat respiratory diseases such as asthma, bronchitis, emphysema and COPD although DPIs have also been used in the treatment of diabetes mellitus.DPIs are an alternative...
for lower respiratory conditions.
Essex pharma markets the medication under the brand name Ecural and Progreś Laboratories markets it under mometAid.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa
Otitis externa
Otitis externa is an inflammation of the outer ear and ear canal. Along with otitis media, external otitis is one of the two human conditions commonly called "earache". It also occurs in many other species. Inflammation of the skin of the ear canal is the essence of this disorder...
under the brand name Mometamax.