Metastasis suppressor

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Metastasis suppressor

A metastasis suppressor is a protein that acts to slow or prevent metastases (secondary tumor

Tumor

A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells . Tumor is not synonymous with cancer. A tumor can be Benign neoplasm, Carcinoma in situ or malignant, whereas cancer is by definition malignant....
s) from spreading in the body of an organism with cancer

Cancer

Cancer is a class of diseases in which a group of cell display uncontrolled growth , invasion , and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize....
. These proteins are different from ones that act to suppress tumor growth

Tumor suppressor gene

A tumor suppressor gene, or antioncogene is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes....
. Genes for about a dozen such proteins are known in humans and other animals, including BRMS1

BRMS1

Breast cancer metastasis suppressor 1, also known as BRMS1, is a human gene.ReferencesFurther reading...
, CRSP3

CRSP3

Cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa, also known as CRSP3, is a human gene....
, DRG1

DRG1

Developmentally regulated GTP binding protein 1, also known as DRG1, is a human gene.ReferencesFurther reading...
, KAI1, KISS1, NM23, and various TIMPs.

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