McLafferty rearrangement
Encyclopedia
The McLafferty rearrangement is a reaction observed in mass spectrometry
. It is sometimes found that a molecule containing a keto-group undergoes β-cleavage, with the gain of the γ-hydrogen atom. This rearrangement may take place by a radical or ionic mechanism.
in 1959.
Mass spectrometry
Mass spectrometry is an analytical technique that measures the mass-to-charge ratio of charged particles.It is used for determining masses of particles, for determining the elemental composition of a sample or molecule, and for elucidating the chemical structures of molecules, such as peptides and...
. It is sometimes found that a molecule containing a keto-group undergoes β-cleavage, with the gain of the γ-hydrogen atom. This rearrangement may take place by a radical or ionic mechanism.
The reaction
A description of the reaction was first published by the American chemist Fred McLaffertyFred McLafferty
Fred Warren McLafferty is an American chemist known for his work in mass spectrometry. He is best known for the McLafferty rearrangement reaction that was observed with mass spectrometry. WIth Roland Gohlke, he pioneered the technique of gas chromatography-mass spectrometry...
in 1959.
