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The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen
Spleen

The spleen is an organ found in all vertebrate animals. In humans, the spleen is located in the abdomen of the body, where it functions in the destruction of redundant red blood cells, and holds a reservoir of blood....
. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)

A marginal zone also exists in lymph node
Lymph node

A Lymph node is an organ consisting of many types of cells, and is a part of the lymphatic system. Lymph nodes are found all through the body, and act as filters or traps for foreign particles....
s.

s composed of cells derived primarily from the myeloid
Myeloid

The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte....
 compartment of bone marrow
Bone marrow

Bone marrow is the flexible biological tissue found in the hollow interior of bones. In adults, marrow in large bones produces new blood cells....
 differentiation.






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The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen
Spleen

The spleen is an organ found in all vertebrate animals. In humans, the spleen is located in the abdomen of the body, where it functions in the destruction of redundant red blood cells, and holds a reservoir of blood....
. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)

A marginal zone also exists in lymph node
Lymph node

A Lymph node is an organ consisting of many types of cells, and is a part of the lymphatic system. Lymph nodes are found all through the body, and act as filters or traps for foreign particles....
s.

Composition and markers

It is composed of cells derived primarily from the myeloid
Myeloid

The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte....
 compartment of bone marrow
Bone marrow

Bone marrow is the flexible biological tissue found in the hollow interior of bones. In adults, marrow in large bones produces new blood cells....
 differentiation. At least three distinct cellular markers can be used to identify cells of the marginal zone, MOMA-1, ERTR-9 and MARCO
Marco

Marco may refer to:* Marco , people with the given name Marco* 3000 Leagues in Search of Mother, an anime series, in some countries referred to as Marco...
.

Function

The major role of marginal zone is to trap particulate antigen
Antigen

An antigen is a substance that prompts the generation of antibodies and can cause an immune response. The word originated from the notion that they can stimulate antibody generation....
 from the circulation
Circulation

Circulation may refer to:*Circulatory system, a biological organ system whose primary function is to move substances to and from cells*Circulation , the path integral of the fluid velocity around a closed curve...
 and present the antigen to the lymphocytes of the spleen.

Experiments have shown that inert latex
LaTeX

LaTeX is a document markup language and Word processor for the TeX typesetting program. Within the typesetting system, its name is styled as ....
 beads as well as live bacteria such as Escherichia coli
Escherichia coli

'Escherichia coli' , is a Gram negative bacterium that is commonly found in the lower gastrointestinal tract of warm-blooded animals. Most E....
 and Listeria monocytogenes
Listeria monocytogenes

Listeria monocytogenes, one of the most virulent foodborne pathogens with 20 percent of clinical infections resulting in death, is the causative agent of Listeriosis....
 are trapped by the marginal zone. However, only immunogenic substances, ie. bacteria
Bacteria

The Bacteria are a large group of unicellular microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals....
, are trafficked to the T and B cell zones of the white-pulp and are efficiently presented to elicit an immune response.

Lymphocytes

Marginal zone lymphocytes are a type of B cell
B cell

B cells are lymphocytes that play a large role in the humoral immunity . The principal functions of B cells are to make antibody against antigens, perform the role of Antigen Presenting Cells and eventually develop into memory B cells after activation by antigen interaction....
 ("MZ B cell") created there, capable of binding IgM
IGM

IGM might be an acronym or abbreviation for:* The polymeric Antibody, Immunoglobulin M* Grandmaster , a chess ranking* intergalactic medium...
-antigen complexes. They are notable for their ability to serve several different roles in the immune system
Immune system

An immune system is a collection of biological processes within an organism that protects against disease by identifying and killing pathogens and tumour cells....
.

See also

  • Marginal zone B-cell lymphoma
    Marginal zone B-cell lymphoma

    Marginal zone B-cell lymphoma is a type of B-cell lymphoma presenting primarily in the marginal zone.There are three types:* Splenic marginal zone lymphoma...
  • Humoral immunity
    Humoral immunity

    The Humoral Immune Response is the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage ....


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