LY-379,268
Encyclopedia
LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3
).
It is derived from the older mGluR group II agonist eglumegad
, and led on to the development of the more potent compound LY-404,039
, but is still widely used in research itself. LY-379,268 has sedative
, neuroprotective, anti-addictive and anticonvulsant
effects in animals, and blocks the effects of PCP
and DOI
, which has led to research into LY-379,268 and similar compounds as antipsychotic
drugs for the treatment of schizophrenia
.
There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist
.
Metabotropic glutamate receptor
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs...
).
It is derived from the older mGluR group II agonist eglumegad
Eglumegad
Eglumegad is a research drug developed by Eli Lilly and Company, which is being investigated for its potential in the treatment of anxiety and drug addiction. It is a glutamate derived compound and its mode of action implies a novel mechanism....
, and led on to the development of the more potent compound LY-404,039
LY-404,039
LY-404,039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation....
, but is still widely used in research itself. LY-379,268 has sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
, neuroprotective, anti-addictive and anticonvulsant
Anticonvulsant
The anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and in the treatment of neuropathic pain. The goal of an...
effects in animals, and blocks the effects of PCP
Phencyclidine
Phencyclidine , commonly initialized as PCP and known colloquially as angel dust, is a recreational dissociative drug...
and DOI
2,5-Dimethoxy-4-iodoamphetamine
2,5-dimethoxy-4-iodoamphetamine is a psychedelic drug and a substituted amphetamine of the phenethylamine family. It is also a powerful anti-inflammatory that is effective at doses on the order of 100 micrograms in humans, far below its effective dose as a psychedelic. Despite being a substituted...
, which has led to research into LY-379,268 and similar compounds as antipsychotic
Antipsychotic
An antipsychotic is a tranquilizing psychiatric medication primarily used to manage psychosis , particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s...
drugs for the treatment of schizophrenia
Schizophrenia
Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...
.
There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist
Partial agonist
Partial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
.