Kentucky Route 22 is a 100.991 miles (162.5 km) east–west highway running from the eastern suburbs of Louisville

Louisville, Kentucky

Louisville is the largest city in the U.S. state of Kentucky, and the county seat of Jefferson County. Since 2003, the city's borders have been coterminous with those of the county because of a city-county merger. The city's population at the 2010 census was 741,096...

 to an unincorporated place called Willow in Bracken County

Bracken County, Kentucky

Bracken County is a county located in the U.S. state of Kentucky. It was formed in 1797. The population was 8,488 in the 2010 Census. Its county seat is Brooksville, Kentucky.-History:...

 in Northern Kentucky

Kentucky

The Commonwealth of Kentucky is a state located in the East Central United States of America. As classified by the United States Census Bureau, Kentucky is a Southern state, more specifically in the East South Central region. Kentucky is one of four U.S. states constituted as a commonwealth...

.

Route 22 has a short (0.332 mile) business route in Dry Ridge

Dry Ridge, Kentucky

Dry Ridge is a city in Grant County, Kentucky, United States. The population was 1,995 at the 2000 census.-Geography:Dry Ridge is located at ....

, an area which has become a commercial center as an I-75 exit.

It begins at US 42 at the city limit of a Louisville suburb called Northfield, Kentucky

Northfield, Kentucky

Northfield is a city in Jefferson County, Kentucky, United States. The population was 970 at the 2000 census.-Geography:Northfield is located at ....

, and carries the name Brownsboro Road, a local road which begins near Downtown Louisville. It crosses the Kentucky River west of Gratz

Gratz, Kentucky

Gratz is a city in Owen County, Kentucky, United States. Founded in 1847, it was named for B. Gratz Brown, who later became Governor of Missouri...

 and terminates at Kentucky Route 10 in Willow.