Karak syndrome is a novel and a member of the growing family of neurological diseases involving excess cerebral iron

Iron

Iron is a chemical element with the symbol Fe and atomic number 26. It is a metal in the first transition series. It is the most common element forming the planet Earth as a whole, forming much of Earth's outer and inner core. It is the fourth most common element in the Earth's crust...

 accumulation. The family who the disease was discovered in their siblings lived in Karak

Al Karak

Karak is a city in Jordan that is known for the famous crusader castle Kerak. The castle is one of the three largest castles in the region, the other two being in Syria...

, a town in southern Jordan

Jordan

Jordan , officially the Hashemite Kingdom of Jordan , Al-Mamlaka al-Urduniyya al-Hashemiyya) is a kingdom on the East Bank of the River Jordan. The country borders Saudi Arabia to the east and south-east, Iraq to the north-east, Syria to the north and the West Bank and Israel to the west, sharing...

. It is characterized by ataxia

Ataxia

Ataxia is a neurological sign and symptom that consists of gross lack of coordination of muscle movements. Ataxia is a non-specific clinical manifestation implying dysfunction of the parts of the nervous system that coordinate movement, such as the cerebellum...

, inverted feet (calcaneovarus), dysarthric scanning speech with dystonic features, dystonic movement of the tongue

Tongue

The tongue is a muscular hydrostat on the floors of the mouths of most vertebrates which manipulates food for mastication. It is the primary organ of taste , as much of the upper surface of the tongue is covered in papillae and taste buds. It is sensitive and kept moist by saliva, and is richly...

 and facial muscles

Facial muscles

The facial muscles are a group of striated muscles innervated by the facial nerve that, among other things, control facial expression. These muscles are also called mimetic muscles.-Structure:...

 and choreiform movement was present in both upper and lower limbs, being more marked in the lower limbs, along with dystonic posture

Human position

Human positions refers to the different positions that the human body can take.There are several synonyms that refer to the human position, often used interchangeably, but having specific flavors....

 of the distal feet, bradykinesia
present in both upper and lower limbs, dysmetria

Dysmetria

Dysmetria refers to a lack of coordination of movement typified by the undershoot or overshoot of intended position with the hand, arm, leg, or eye...

, dysdiadochokinesia

Dysdiadochokinesia

Dysdiadochokinesia, dysdiadochokinesis, dysdiadokokinesia, dysdiadokokinesis, or DDK is the medical term for an inability to perform rapid, alternating movements.-Causes:It is a feature of cerebellar ataxia, and is the result of lesions to the cerebellar hemispheres, the posterior or...

, and intentional tremor

Tremor

A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving to-and-fro movements of one or more body parts. It is the most common of all involuntary movements and can affect the hands, arms, eyes, face, head, vocal folds, trunk, and legs. Most tremors occur in the...

were bilateral and symmetrical.